| 1-(2-氯苯基)-5(4H)-四唑啉酮的合成研究 |
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| 引用本文： | 潘忠稳,凌冰,姚琼.1-(2-氯苯基)-5(4H)-四唑啉酮的合成研究[J].精细化工,2002,19(3):177-178. |
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| 作者姓名： | 潘忠稳 凌冰 姚琼 |
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| 作者单位： | 安徽省化工研究院农药合成室,安徽,合肥,230041 |
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| 基金项目： | 安徽省优秀青年科技基金项目资助 (No.3 1)~~ |
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| 摘 要： | 1 (2 氯苯基 ) 5 (4H) 四唑啉酮 (Ⅰ)可由 2 氯硝基苯经三步合成反应制得。首先 ,2 氯硝基苯经铁粉还原得 2 氯苯胺 (Ⅱ) ,Ⅱ与碳酸二 (三氯甲基 )酯反应得 2 氯苯基异氰酸酯 (Ⅲ ) ,Ⅲ在DMF溶剂中 ,无水三氯化铝催化下与叠氮钠缩合得Ⅰ。三步收率分别为 90 %、80 %、90 % ,总收率为 6 5 %(以邻氯硝基苯计 ) ,产品质量分数达 95 %。
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| 关 键 词： | 1-(2-氯苯基)-5(4H)-四唑啉酮 2-氯硝基苯 |
| 文章编号： | 1003-5214(2002)03-0177-02 |
Synthesis of 1 - ( 2-Chlorophenyl ) -5 ( 4H ) -tetrazolinone |
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| PAN Zhong wen,LING Bing,YAO Qiong.Synthesis of 1 - ( 2-Chlorophenyl ) -5 ( 4H ) -tetrazolinone[J].Fine Chemicals,2002,19(3):177-178. |
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| Authors: | PAN Zhong wen LING Bing YAO Qiong |
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| Abstract: | 1-(2-Chlorophenyl) 5(4H) tetrazolinone(Ⅰ) was synthesized by three step reaction.2 Chloronitrobenzene was reduced with iron powder in conc.HCl to give 2 chloroaniline(Ⅱ) in 90% yield.Then Ⅱ reacted with bis(trichloromethyl) carbonate (trimer of phosgene) to form 2 chlorophenyl isocyanate(Ⅲ) in 80% yield.Finally,I was produced in 90% yield by condensation of Ⅲ and sodium azide in N,N dimethylformamide in the presence of anhydrous AlCl 3.The total yield was 65%.Purity of the product could reach 95%. |
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| Keywords: | 1-(2-chlorophenyl) 5(4H) tetrazolinone 2 chloronitrobenzene |
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