| 幽门螺杆菌感染与胃粘膜增殖细胞核抗原表达的关系 |
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| 引用本文： | 姜海行, 胡翠娥, 梁秀就.幽门螺杆菌感染与胃粘膜增殖细胞核抗原表达的关系[J].世界华人消化杂志,1997,5(4):223-224. |
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| 作者姓名： | 姜海行 胡翠娥 梁秀就 |
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| 作者单位： | 530027,广西南宁市,广西医科大学第一附属医院消化内科. |
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| 摘 要： | 目的探讨幽门螺杆菌（Ｈｐ）感染对胃粘膜细胞增殖活性的影响．方法采用免疫组化法，观察３４例Ｈｐ阳性的慢性胃病患者（男１９例，女１５例）胃窦粘膜增殖细胞核抗原标记指数（ＰＣＮＡＬＩ），同时以１２例Ｈｐ阴性的慢性胃病患者作对照，并对Ｈｐ阳性患者进行抗Ｈｐ治疗，４周后复查ＰＣＮＡＬＩ．结果Ｈｐ感染胃窦粘膜ＰＣＮＡＬＩ较无Ｈｐ感染显著增高（２９０２±１０２３比１４３１±６８７，Ｐ＜００１）；Ｈｐ根除（ｎ＝２４）后胃窦粘膜ＰＣＮＡＬＩ由２８１１±１１５降至１７６８±９６５（Ｐ＜００１），而Ｈｐ未根除（ｎ＝１０）时则无显著降低（２９１７±８１４→２４４２±７４４，Ｐ＞００５）．Ｈｐ感染时胃粘膜ＰＣＮＡＬＩ与炎症程度正相关（Ｐ＜００５），但与Ｈｐ菌量无相关（Ｐ＞００５）．结论Ｈｐ感染可增加胃粘膜细胞增殖活性，从而增加胃癌发生的危险性，根除Ｈｐ后可纠正这一变化，对预防胃癌发生可能有重要意义．
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| 关 键 词： | 螺杆菌，幽门 螺杆菌感染／免疫学 胃粘膜／免疫学 增殖细胞核抗原／代谢 |
Relationship between Helicobacter pylori infection and expression of proliferating cell nuclear antigen in gastric mucosa |
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| JIANG Hai Xing ,HU Cui E and LIANG Xiu Jiu.Relationship between Helicobacter pylori infection and expression of proliferating cell nuclear antigen in gastric mucosa[J].World Chinese Journal of Digestology,1997,5(4):223-224. |
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| Authors: | JIANG Hai Xing HU Cui E and LIANG Xiu Jiu |
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| Affiliation: | JIANG Hai Xing 1,HU Cui E 2 and LIANG Xiu Jiu 3 Department of Gastroenterology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530027,Guangxi Province,China |
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| Abstract: | AIM To explore the effect of Helicobacter pylori (Hp) infection on the proliferating activity of gastric mucosa. METHODS The expressions of proliferating cell nuclear antigen labeling index (PCNA LI) in patients with Hp infection ( n =34, males 19, females 15) were semiquantitatively investigated and followed up after anti Hp therapy with immunohistochemical staining technique. |
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| Keywords: | Helicobacter pylori Helicobacter infections/immunology Gastric mucosa/immunology Proliferating cell nuclear antigen/metabolism |
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