| 轻度认知功能障碍的生物学标志 |
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| 引用本文： | 谭忠林,周江宁. 轻度认知功能障碍的生物学标志[J]. 国际脑血管病杂志, 2004, 12(6): 453-456 |
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| 作者姓名： | 谭忠林 周江宁 |
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| 作者单位： | 230027,合肥,中国科学技术大学生命科学学院神经生物学系;230027,合肥,中国科学技术大学生命科学学院神经生物学系 |
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| 摘 要： | 轻度认知功能障碍是正常衰老和痴呆间的一种过渡状态 ,可分为遗忘型和血管型等亚型 ,其概念和诊断正趋向一致。轻度认知功能障碍老年人和痴呆患者在脑脊液Tau蛋白、Aβ、Aβ前体蛋白、胆碱乙酰转移酶活性和事件相关电位等方面有类似变化。文章总结了轻度认知功能障碍的诊断和部分神经生物学指标。
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| 关 键 词： | 轻度认知功能障碍 Tau蛋白 Aβ蛋白 事件相关电位 |
| 修稿时间： | 2003-08-19 |
Biomarkers in Mild Cognitive Impairment |
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| Tan Zhonglin,Zhou Jiangning. Biomarkers in Mild Cognitive Impairment[J]. International Journal of Cerebrovascular Diseases, 2004, 12(6): 453-456 |
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| Authors: | Tan Zhonglin Zhou Jiangning |
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| Affiliation: | Tan Zhonglin,Zhou Jiangning Department of Neurobiology,School of Life Science,University of Science and Technology of China,Hefei 230027,China |
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| Abstract: | Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia, which can be divided into amnestic MCI and vascular MCI. They tend to be coincident with their concept and diagnosis. There are similar biological changes in older patients with MCI and Alzheimer's disease, including Tau protein, beta-amyloid protein, amyloid precursor protein, choline acetyltransferase activity and event-related potentials. This article summarizes the latest progress in the diagnosis of MCI and part of neurobiological parameters. |
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