术后131I治疗对甲状腺癌唾液腺功能与甲状腺球蛋白抗体影响

【摘要】 目的 探讨术后131I治疗对甲状腺癌唾液腺功能与甲状腺球蛋白抗体(TgAb)影响。方法〓我院甲状腺癌手术后接受131I治疗患者79例,其中40例患者给予150 mCi 131I治疗(150 mCi组),39例给予80 mCi8 131I治疗(80 mCi组),比较两组唾液腺功能和TgAb水平的差异。结果〓150 mCi组治疗有效率稍高于80 mCi组,但两组比较差异无统计学意义(P>0.05),150 mCi组唾液初始pH值与唾液缓冲pH值明显高于80 mCi组,唾液流率明显低于80 mCi组,两组比较差异具有统计学意义(P<0.05),131I治疗后3、6个月,150 mCi组平均TgAb水平明显低于80 mCi组(P<0.05)。结论〓术后131I治疗对甲状腺癌临床疗效显著,其中低剂量131I治疗对唾液腺不良反应程度较低,而高剂量131I治疗有助于TgAb水平的降低。

Postoperative 131I effect of salivary gland function and thyroglobulin antibody for thyroid carcinoma

【Abstract】〓Objective〓To investigate the effect of the postoperative 131I treatment on salivary gland function and Thyroglobulin antibody (TgAb) for thyroid carcinoma. Methods〓Seventy-nine cases of thyroid carcinoma surgery patients in our hospital were included. Forty patients were treated with 150 mCi 131I (150 mCi group) and thirty-nine patients with 80 mCi 131I (80 mCi group). Salivary gland function and TgAb levels of patients were compared between the two groups. Results〓Effective rate of 150 mCi group was slightly higher than of 80 mCi group, but it had not statistically significant difference between the two groups. Saliva pH value and salivary buffer pH value of 150 mCi group were significantly higher than 80 mCi group. Salivary flow rate was significantly lower than 80 mCi group(P<0.05),and 3,6 months after 131I therapy, the average TgAb of 150 mCi group were significantly lower than 80 mCi group (P<0.05). Conclusion〓In our study, the effect of 131I therapy was remarkable for treatment of thyroid carcinoma, and it had less adverse reaction in low dose 131I therapy, but the TgAb more dropping degree in high dose 131I therapy.