| 丹皮酚对钙反常培养心肌细胞的保护作用 |
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| 引用本文： | 唐景荣,石琳.丹皮酚对钙反常培养心肌细胞的保护作用[J].中国中药杂志,1991,16(9):557-560. |
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| 作者姓名： | 唐景荣 石琳 |
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| 作者单位： | 潍坊医学院,261042 |
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| 摘 要： | 丹皮酚能显著抑制正常心肌细胞快相(5min)和慢相(120min)45Ca摄取及搏动频率,显著抑制钙反常心肌细胞45Ca摄取和降低胞内过氧化脂质含量,且呈剂量依赖性。表明丹皮酚减轻钙反常损伤与阻止Ca2+内流及抗氧化有关。
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| 关 键 词： | 丹皮酚 培养乳鼠心肌细胞 钙反常 45Ca摄取 过氧化脂质 |
| 收稿时间： | 1990/1/17 0:00:00 |
The Protective Effects of Paeonol on Cultured Neonatal Rat Heart Cells During Calcium Paradox |
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| Tang Jingrong.The Protective Effects of Paeonol on Cultured Neonatal Rat Heart Cells During Calcium Paradox[J].China Journal of Chinese Materia Medica,1991,16(9):557-560. |
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| Authors: | Tang Jingrong |
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| Affiliation: | Tang Jingrong(Weifang Medical College 261042) Shi Lin (Suzhou Medical College 215007) |
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| Abstract: | It has been found that the rapid (5min) and slow (120min) phases of 45Ca uptake by normal myocardial cells and their beating rate are remarkably inhibited by paeonol. And that paeonol can also decrease 45Ca uptake and lipid peroxide in calcium paradoxical heart cells, which appears in dose-dependence. This indicates that the mechanism of protection of paeonol against calcium paradox is associated with its inhibition of Ca2+) influx and antioxidation. |
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| Keywords: | paeonol cultured neonatal rat heart cells calcium paradox 45Ca uptake lipid peroxide |
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