桉油对丙酸氮倍他索乳膏经皮渗透和吸收的作用

目的：考察促进剂桉油对丙酸氯倍他索（CBT）乳膏经皮渗透的促进作用，通过比较透过量和皮层中量，分析在该制剂中是否透合使用桉油，方法：采用直立式扩散池，考察了桉油在0．5％，1．0％，5．0％浓度下0．05％CBT乳膏经皮渗透2，4，6，8，10，24h后单位面积累积透过量Q(ug.cm^-2)和稳态透皮流量J（ug.cm^-2.h^-1);HPLC法测定经皮渗透24h后每克皮肤组织中CBT的量D（ug.g^-1),结果：4种浓度的桉油均显著促进CBT乳膏透皮吸收（P＜0．01），其J值约是对照组的3－5倍（P＜0．01），随浓度增加，陂层量D并不随之相应增加，结论：桉油可加快CBT经皮渗透速度，也能增加皮层中CBT量，但有饱和性，建议CBT 乳膏膏以少加（＜50％）或不加桉油为好。

Effect of eucalyptus oil on the percutaneous penetration and absorption of clobetasol propionate cream

OBJECTIVE：To evaluate the effect of eucalyptus oil on percutaneous penetration and absorption of clobetasol propionate (CBT) cream.METHODS：With vertical permusion cell,in vitro penetration of CBT through excised mouse abdominal skin in the present of eucalyptus oil at its four concentrations was conducted with 0.05% CBT cream.The cumulative amount (Q,μg*cm-2) of this study at 2,4,6,8,10,24 h was got and the steady-state flux (J,μg*cm-2*h-1) was determined.The quantities of CBT (D,μg*g-1) within the whole strata of skin after 24 hours in vitro treatment were investigated.RESULTS：Eucalyptus oil as an enhancer could highly increase,Q and J of CBT within skin,but D was not proportional to the concentrations of eucalyptus oil.CONCLUSIONS：On the basis of data presented herein,we can suggest that it's better for CBT cream,eucalyptus oil not use/or less use (0.5%),because eucalyptus oil would increase CBT percutaneous absorption which might lead to unwanted systemic effects.