| 抑菌剂1,2-苯并异噻唑啉-3-酮(BIT)的合成研究 |
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| 引用本文： | 童国通,翁建全.抑菌剂1,2-苯并异噻唑啉-3-酮(BIT)的合成研究[J].化学世界,2013,54(4):231-232,236,240. |
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| 作者姓名： | 童国通 翁建全 |
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| 作者单位： | 1. 杭州职业技术学院,浙江杭州,310018
2. 浙江工业大学化学工程与材料学院,浙江杭州,310032 |
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| 基金项目： | 杭州市高校绿色精细化工研究与技术转化重点实验室项目 |
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| 摘 要： | 研究了一种以2,2’-二硫代苯甲酸为原料,用双(三氯甲基)碳酸酯替代氯化亚砜进行酰氯化反应制得2,2’-二硫代苯甲酰氯,然后在氨溶液中通空气进行歧化环合制得抑菌剂1,2-苯并异噻唑啉-3-酮(BIT)的合成方法,该方法操作方便,具有工业化应用前景。研究讨论了影响反应的多种因素并得到比较合理的工艺条件,总收率达78.2%。对产品结构进行了1 H NMR表征确认。
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| 关 键 词： | 1 2-苯并异噻唑啉-3-酮 酰氯化反应 环合反应 抑菌剂 |
Study on Synthesis of 1,2-Benzisothiazolin-3-one |
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| TONG Guo-tong,WENG Jian-quan.Study on Synthesis of 1,2-Benzisothiazolin-3-one[J].Chemical World,2013,54(4):231-232,236,240. |
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| Authors: | TONG Guo-tong WENG Jian-quan |
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| Affiliation: | 1.Hangzhou Vocational and Technical College,Zhejiang Hangzhou 310018,China; 2.College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Zhejiang Hangzhou 310032,China) |
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| Abstract: | A new process of preparing 1,2-benzisothiazolin-3-one,a widely used bacteriostatic agent,was introduced.2,2'-dithiobenzoyl chloride was synthesized by acylation reaction of 2,2'-dithiobenzoic acid with dimethyl carbonate in toluene,then was cyclizated by air in ammonia solution to obtain the title compound.The optimum reaction conditions for every reaction step were studied.The total yield of 1,2-benzisothiazolin-3-one was 78.2 %.The structure of the product was confirmed by 1H NMR spectroscopy. |
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| Keywords: | 1 2-benzisothiazolin-3-one acyl chloride cyclization bacteriostatic agent |
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