| 碘代醚类化合物的合成研究 |
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| 引用本文： | 钟燕,梁占超,刘靖,张首国,温晓雪,彭涛,王林.碘代醚类化合物的合成研究[J].化学试剂,2011,33(10):871-872,918. |
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| 作者姓名： | 钟燕 梁占超 刘靖 张首国 温晓雪 彭涛 王林 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所,北京,100850 |
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| 基金项目： | 国家自然科学基金资助项目(307706558,1072531,30472081) |
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| 摘 要： | 碘代化合物是有机合成化学中的一种重要的中间体.探索了碘代醚类化合物的合成方法.以己二醇为原料,经碘代、成醚,碘化合成了碘代硫醚类化合物,产率达23.5％.以己二醇单碘代中间体为原料,经保护、成醚、脱保护,碘化合成了碘代醚类化合物,产率达30.5％.本合成方法工艺简便、条件温和、原料易得.
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| 关 键 词： | 碘代脂肪烷 碘代 中间体 合成 |
Synthesis of iodo-substituted ethers |
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| ZHONG Yan,LIANG Zhan-chao,LIU Jing,ZHANG Shou-guo,WEN Xiao-xue,PENG Tao,WANG Lin.Synthesis of iodo-substituted ethers[J].Chemical Reagents,2011,33(10):871-872,918. |
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| Authors: | ZHONG Yan LIANG Zhan-chao LIU Jing ZHANG Shou-guo WEN Xiao-xue PENG Tao WANG Lin |
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| Affiliation: | ZHONG Yan,LIANG Zhan-chao,LIU Jing,ZHANG Shou-guo,WEN Xiao-xue,PENG Tao,WANG Lin (Institute of Radiation Medicine,Academy of Military Medicial Sciences,Beijing 100850,China) |
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| Abstract: | The iodo-substitued compounds are the important intermediates in organic synthesis.The synthesis of iodo-substituted ethers were investigated.Hexanediol,as the starting material,was subjected to iodo-substitution,etherification and iodination to give iodo-substituted sulfides.The total yield was 30.5%.The mono-iodo-substitueted intermediate was subjected to protection,etherification,deprotection and iodination to give iodo-substituted ethers.The total yield was 30.5%.The starting material is very easy to be... |
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| Keywords: | iodo-substituted ethers iodination intermediate synthesis |
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