| 补体在IgA肾病发生发展中的作用 |
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| 作者姓名： | 张岩 段姝伟 蔡广研 陈香美 |
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| 作者单位： | 1. 100853 北京，解放军总医院第一医学中心肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室（2011DAV00088）、国家慢性肾病临床医学研究中心、 肾脏疾病研究北京市重点实验室 |
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| 基金项目： | 北京市科委IgA肾病项目(D181100000118002) |
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| 摘 要： | IgA肾病的发生与自身免疫相关，其特征为肾小球系膜区IgA沉积。IgA肾病的发病机制尚不清楚，但现已证实补体异常活化在IgA肾病发生发展中起重要作用，参与IgA肾病发生发展过程的主要为补体替代途径和凝集素途径。本文就补体系统在IgA肾病发生发展中的作用进行了综述。
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| 关 键 词： | IgA肾病 补体系统 替代途径 凝集素途径 |
| 收稿时间： | 2019-04-02 |
The role of the complements in the development of IgA nephropathy |
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| Authors: | Yan Zhang Shuwei Duan Guangyan Cai Xiangmei Chen |
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| Affiliation: | 1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Nephrology, Beijing 100853, China |
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| Abstract: | IgA nephropathy is considered as an autoimmune disease, and characterized by the deposition of IgA in the mesangium of glomeruli. The pathogenesis of IgA nephropathy is not clear, but it has been confirmed that the complement system abnormally activated plays a critical role in the development of IgA nephropathy. Recent studies indicated that the complement activation in IgA nephropathy is mainly via the alternative pathway and lectin pathway. In this review, the contribution of the complement system to the IgA nephropathy was summarized. |
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| Keywords: | IgA nephropathy Complement system Alternative pathway Lectin pathway |
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