新生儿缺血缺氧性脑病对早产儿排尿方式的影响

目的 探讨新生儿缺血缺氧性脑病(HIE)对早产儿排尿方式的影响.方法 选取出生后4～15d确诊为新生儿缺血缺氧性脑病早产儿48例,男34例,女14例,孕(32.1±0.7)周,出生时体重(2.5±0.3)kg.选取同期出生后4～15d无缺血缺氧性脑病的33例早产儿为对照组,男22例,女11例,孕(32.3±1.4)周,出生时体重(2.4±0.5)kg.记录4h(早上8点～10点)排尿情况,包括排尿量、残余尿量、排尿次数等参数,同时记录饮奶量、液体输入量及摄入时间,液体摄入量按标准进行.结果共记录了248次排尿,其中HIE组136次,对照组112次.HIE组排尿量和排空比例分别为(14.8±8.3)ml和11.6％,均显著小于对照组(16.5±9.2)ml和24.3％]；而HIE组的排尿次数、平均残余尿量分别为(2.8±1.1)次、(1.5±1.3)ml,对照组为(3.3±1.2)次、(1.7±0.9)ml,两者之间的差异无统计学意义.结论 缺血缺氧性脑病可使早产儿出现一定程度排空和储尿障碍,表现为每次排尿量及排空比例降低.

A study on voiding pattern in preterm newborns with hypoxic-ischemic encephalopathy

Objective To investigate the voiding pattern in preterm neonates affected by hypoxic-ischemic encephalopathy (HIE).Methods A total of 81 preterm newborns aged 4 to 15 days at The First Affiliated Hospital of Zhengzhou University from March to October 2010 were included in this study,48 of them affected by HIE (32.1 ± 0.7 weeks of gestation) with weight of 2.5 ± 0.3 kg,the other 33 preterm were normal (32.3 ± 1.4) weeks of gestation,body weight: 2.4 ± 0.5 kg).The voided volume,post void residual (PVR) volume,voiding frequency per 4 hours as well as the quantity of milk and liquid intake within the same time schedule for 4 hours from 8AM to 12AM were recorded.The liquid intake was given according to standard protocol.Results A total of 248 times of voiding were recorded.Voided volume and bladder empty percentage was significant lower in newborn with HIE comparing to controls (14.4 ± 8.3) ml vs.(16.5 ± 9.2) ml and 11.6％ vs.24.3％,(P＜0.05),respectively],whereas voiding frequency,PVR volume showed no significant difference.Conclusions The difference of voiding patterns between newborn with HIE and controls indicates HIE has a significant effect on the bladder storage and voiding function.