| 胡蔓藤中非生物碱类化学成分的分离与鉴定 |
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| 引用本文： | 赵庆春,付艳辉,郭涛,华威,吴立军.胡蔓藤中非生物碱类化学成分的分离与鉴定[J].沈阳药科大学学报,2007,24(10):619-622. |
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| 作者姓名： | 赵庆春 付艳辉 郭涛 华威 吴立军 |
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| 作者单位： | 1. 沈阳军区总医院,药剂科,辽宁,沈阳,110016
2. 沈阳药科大学,中药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的对胡蔓藤的非生物碱类化学成分进行研究。方法采用HPD-800大孔吸附树脂柱色谱、硅胶柱色谱和ODS中压柱色谱进行分离,采用葡聚糖凝胶(Sephadex LH-20)及制备液相进行纯化,根据理化性质和光谱学数据鉴定结构。结果得到8个化合物,分别鉴定为β-谷甾醇(β-sitosterol,1)、豆甾醇(stigmasterol,2)、胡萝卜苷(daucosterol,3)、豆甾醇-3-O-β-D-吡喃葡萄糖苷(stigmasterol-3-O-β-D-glucopyranoside,4)、熊果酸(ursolic acid,5)、没食子酸(gallic acid,6)、阿魏酸(ferulic acid,7)、原儿茶酸(protocatechuic acid,8)。结论化合物1~8均为首次从该属植物中分得。
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| 关 键 词： | 胡蔓藤 化学成分 非生物碱 |
| 文章编号： | 1006-2858（2007）10-0619-04 |
| 修稿时间： | 2006-12-11 |
Isolation and identification of non-alkaloid constituents from Gelsemium elegans Benth. |
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| ZHAO Qing-chun,FU Yan-hui,GUO Tao,HUA Wei,WU Li-jun.Isolation and identification of non-alkaloid constituents from Gelsemium elegans Benth.[J].Journal of Shenyang Pharmaceutical University,2007,24(10):619-622. |
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| Authors: | ZHAO Qing-chun FU Yan-hui GUO Tao HUA Wei WU Li-jun |
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| Affiliation: | 1. Department of Pharmacy, General Hospital of Shenyang Military Region, Shenyang 110016, China; 2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective To investigate the non-alkaloid constituents from Gelsemium elegans Benth.Methods Solvent extraction and column chromatography were used to isolate the non-alkaloid constituents,and physicochemical constants and spectroscopic analysis were employed for structural elucidation.Results Eight compounds were isolated,and their structures were identified as β-sitosterol(1),stigmasterol(2),daucosterol(3),stigmasterol-β-D-glucopyranoside(4),ursolic acid(5),gallic acid(6),ferulic acid(7),protocatechuic acid(8).Conclusion All compounds are obtained from this genus for the first time. |
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| Keywords: | Gelsemium elegans Benth chemical constituents non-alkaloid |
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