| 冠心病合并Ⅱ型糖尿病患者血清MMP-9及高敏C-反应蛋白表达变化及其临床意义 |
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| 引用本文： | 吴伟群,李延辉.冠心病合并Ⅱ型糖尿病患者血清MMP-9及高敏C-反应蛋白表达变化及其临床意义[J].实用预防医学,2011,18(5):893-894. |
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| 作者姓名： | 吴伟群 李延辉 |
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| 作者单位： | 广东省东莞市石碣医院,广东,东莞,523290 |
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| 摘 要： | 目的探讨冠心病（CHD）合并2型糖尿病（T2DM）患者血清基质金属蛋白酶-9（MMP-9）、高敏C反应蛋白（hs-CRP）的表达水平及其临床意义。方法选择我院内科收治的CHD合并T2DM患者45例,单纯T2DM患者40例,单纯CHD患者42例,另选择门诊健康体检者30例为正常对照组。采用酶联免疫吸附法（ELISA）和免疫散射比浊法检测血清MMP9和hs-CRP的表达水平。结果 CHD合并T2DM组血清MMP-9和hs-CRP的表达水平均显著高于单纯CHD组、单纯T2DM组及对照组（P〈0.05）,单纯CHD组和单纯T2DM组血清MMP-9和hs-CRP的表达水平均显著高于对照组。经Spearman分析,CHD合并T2DM组患者血清MMP-9与hs-CRP呈正相关（r=0.526,P〈0.01）。结论联合检测血清MMP-9与hs-CRP将更有利于早期监测糖尿病冠状动脉粥样硬化的发生和预测患者的预后。
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| 关 键 词： | 冠心病 2型糖尿病 基质金属蛋白酶-9 高敏C反应蛋白 |
Expression Changes and Clinical Significance of Serum MMP-9 and hs-CRP in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus |
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| WU Wei-qun,LI Yan-hui.Expression Changes and Clinical Significance of Serum MMP-9 and hs-CRP in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus[J].Practical Preventive Medicine,2011,18(5):893-894. |
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| Authors: | WU Wei-qun LI Yan-hui |
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| Affiliation: | WU Wei-qun,LI Yan-hui(Shijie Hospital of Dongguan,Dongguan 523290,Guangdong,China) |
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| Abstract: | Objective To explore the expression levels and clinical value of serum matrix meta1loproteinase-9(MMP-9) and high sensitive C-reactive protein(hs-CRP) in coronary heart disease(CHD) patients with type 2 diabetes mellitus(T2DM). Methods Forty-five CHD patients with T2DM,40 patients with T2DM and 42 patients with CHD were selected from Department of Internal Medicine,Shijie Hospital of Dongguan.30 healthy volunteers were served as control group.Serum MMP-9 was measured with ELISA,hs-CRP in serum was measured ... |
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| Keywords: | Coronary heart disease Type 2 diabetes mellitus Matrix meta1loproteinase-9 High sensitive C-reactive protein |
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