药物联合针刺对轻度认知功能障碍患者认知功能的疗效观察

目的探讨尼莫地平联合电针对轻度认知功能障碍（MCI）患者认知改善情况及安全性的影响。方法采用随机对照试验方法,将80例患者分为观察组和对照组,治疗前、治疗1个疗程、2个疗程后分别进行简易精神状态检查（MMSE）量表检测和图形再认实验。结果治疗2个疗程后两组MMSE总评分均较治疗前高（P〈0.01）,且观察组疗效优于单用药物组（P〈0.01）。认知、记忆、言语亚项评分显示,第1个疗程治疗后两组间差异有高度统计学意义（P〈0.01）;第2个疗程治疗结束后认知、记忆亚组有显著性差异（P〈0.05）,言语亚组组间差异无统计学意义（P〉0.05）。图形再认总评分在治疗后有两组显著性差异（P〈0.05）。结论治疗后两组患者综合认知水平均有明显的改善,且观察组疗效优于药物组。

Efficacy of combined treatment of drugs and electric acupunture on cognitive function of patients with mild cognitive impairment

Objective To investigate the efficacy and safety of Nimodipine combined with electric acupuncture（EA） in the enhancement of cognitive function of patients with mild cognitive impairment（MCI）.Methods A randomized controlled trial method was adopted.80 patients were divided into observation group and control group.Mini-mental state examination（MMSE） scale and pattern recognition experiments were given to patients before treatment,after one course treatment and after two courses of treatment.Results After two courses of treatment,total score of MMSE in both groups were significantly different compared with before treatment and the differences were significantly larger in the observation group than in single-drug group（P〈0.01）.The two groups also showed significant differences in cognitive,memory,verbal sub-item scores after the first course of treatment（P〈0.01）;cognitive and memory sub-item scores were also significantly different between the two groups after the second course of treatment（P〈0.05）,while verbal item scores showed no significant difference（P〈0.05）.Pattern recognition total scores of the two groups showed significant differences（P〈0.05） after treatment.Conclusion After treatment,cognitive level has significantly improved in both groups,and the observation group is more effective than the control group.