血管细胞黏附分子-1在结肠癌中的表达及意义

目的研究结肠癌中血管细胞黏附分子-1（VCAM-1）的表达状况及临床意义。方法取结肠癌组织标本及切缘正常结肠组织标本各50例，结肠息肉标本40例，应用免疫组织化学SP法检测所有标本中VCAM-1的表达情况。结果VCAM-1为细胞膜着色。VCAM-1在结肠癌中的阳性表达率为74％，在手术切缘正常结肠组织中的阳性表达率为8％，在结肠息肉中的阳性表达率为20％。VCAM-1在结肠癌中的表达明显高于切缘正常结肠组织和结肠息肉，差异有极显著性意义（均P〈0．01），但正常结肠组织和结肠息肉组织之间VCAM-1的阳性表达差异无显著性意义（P〉0．05）。VCAM-1表达与患者年龄、性别、肿瘤大小、肿瘤位置均无明显相关（均P〉0．05），但与Dukes分期、组织分化程度及有无淋巴结转移相关（均P〈0．05）。结论结肠癌组织中VCAM-1处于过度表达状态，与结肠癌的发生、发展和转移密切相关。

Expression of VCAM-1 in Colon Cancer and Its Significance

Objective To investigate the expression of vascular cell adhesion molecule-1(VCAM-1) in colon cancer and its clinical significance.Methods The samples were obtained from 50 patients with colon cancer and 40 patients with colon polyp.The expression of VCAM-1 was detected in colon carcinoma tissues,normal colic tissues of incisional edge and colon polyp tissues by immunohistochemiscal SP staining method.Results The expression of VCAM-1 was mainly localized in the cell membrane.Positive rate of VCAM-1 expression was 74% in carcinoma tissue,20% in colon polyps and 8% in normal colon tissue of incisional edge respectively.The expression of VCAM-1 in colon carcinoma tissues was significantly higher than that in normal tissues and colon ployp tissues(P<0.01),but there was no significant difference between normal colic tissues of incisional edge and colon polyp tissues(P>0.05).The VCAM-1 expression in carcinoma tissue was significantly correlated with Dukes stage,histological grade and local lymph node involvement(P<0.05),but not with age,gender,site or size of tumor(P>0.05).Conclusion VCAM-1 may play an important role in the occurrence,development and metastasis of colon cancer.