| 医学教育改革、创新与发展 |
| |
| 引用本文： | 张明发,沈雅琴.医学教育改革、创新与发展[J].医学教育探索,2011,26(1):33-35. |
| |
| 作者姓名： | 张明发 沈雅琴 |
| |
| 作者单位： | 上海美优制药有限公司，上海 201422 |
| |
| 摘 要： | 医学教育的根本目的是为人民的健康事业培养合格人才，在医学教育改革中注重医学教育的特点，遵循医学教育的规律，结合实际进行创新，通过创新推动医学教育的发展，是医学教育发展的根本所在。
|
| 关 键 词： | 医学教育 特点和规律 改革创新与发展 |
Glucocorticoid-like effect of glycyrrhizic acid and its aglycone glycyrrhetic acid |
| |
| ZHANG Ming-fa and SHEN Ya-qin.Glucocorticoid-like effect of glycyrrhizic acid and its aglycone glycyrrhetic acid[J].Researches in Medical Education,2011,26(1):33-35. |
| |
| Authors: | ZHANG Ming-fa and SHEN Ya-qin |
| |
| Affiliation: | Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201422, China |
| |
| Abstract: | Abstract: Glycyrrhizic acid is hydrolyzed to glycyrrhetic acid in vivo. Pharmacological action of glycyrrhetic acid is higher than that of glycyrrhizic acid, so glycyrrhizic acid is a prodrug of glycyrrhetic acid. Chemical structure of glycyrrhetic acid is similar to steroid hormone. Glycyrrhetic acid and glycyrrhizic acid are the inhibitors of enzymes in steroid hormone metabolism, therefore they can enhance effects of endogenic and exogenic glucocorticoids. Glycyrrhetic acid and glycyrrhizic acid, as ligands, can combine with glucocorticoid receptor, but receptor activation is far inferior to glucocorticoid. For this reason, glycyrrhetic acid and glycyrrhizic acid are partial agonists of glucocorticoid receptor. In clinic, glycyrrhizic acid may be used as weak glucocorticoid-like drug, not only enhances glucocorticoid effects but also antagonizes adverse reactions of large dose glucocorticoids. |
| |
| Keywords: | glycyrrhizic acid glycyrrhetic acid glucocorticoid-like effect glucocorticoid-like receptor hormone metabolism |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《医学教育探索》浏览原始摘要信息 |
|
点击此处可从《医学教育探索》下载全文 |
|
