Low Postprandial Circulating Inactive Ghrelin: Role of Early Satiety in Undernourished Children期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Low Postprandial Circulating Inactive Ghrelin: Role of Early Satiety in Undernourished Children

Authors:	Khadijehsadat Najib Mozhgan Moghtaderi Shirin Farjadian Ebrahim Falahzadeh

Affiliation:	1. Allergy Research Center, Shiraz University of Medical Sciences, Zand St, 71348-45794, Shiraz, Iran 2. Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran 3. Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran 4. Department of Gastroenterology, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract:	Objective To determine difference in the levels of circulating inactive ghrelin between undernourished and healthy children. Methods The present cross-sectional study was conducted in undernourished children from southwestern Iran, from July 2011 through July 2012. Postprandial inactive ghrelin levels were measured in 40 undernourished children and sex- and age-matched healthy controls by enzyme immunoassay. Results The levels of postprandial inactive ghrelin were considerably lower in undernourished compared to the healthy children (6.4 vs. 12.9, P?vs. 7.1, P?=?0.032). Conclusions Thus, the levels of inactive ghrelin was found to be low in undernourished children compared to healthy children. Early loss of appetite might be a result of low circulating inactive ghrelin levels in the postprandial state in undernourished children.

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