| 利福平脂质体温敏型原位凝胶的制备及其体外释药特征研究 |
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| 引用本文： | 曹佳薇,倪坚军,姚君,周峰,周中元,徐颖颖,蔡鑫君.利福平脂质体温敏型原位凝胶的制备及其体外释药特征研究[J].中国现代应用药学,2016,33(2):183-187. |
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| 作者姓名： | 曹佳薇 倪坚军 姚君 周峰 周中元 徐颖颖 蔡鑫君 |
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| 作者单位： | 浙江省中西医结合医院药剂科，杭州 310003,浙江省中西医结合医院药剂科，杭州 310003,浙江省中西医结合医院药剂科，杭州 310003,浙江省中西医结合医院药剂科，杭州 310003,浙江省中西医结合医院药剂科，杭州 310003,浙江省中西医结合医院药剂科，杭州 310003,浙江省中西医结合医院药剂科，杭州 310003 |
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| 基金项目： | 杭州市卫生科技计划项目(2013A43)；杭州市科技计划引导项目(20130733Q14) |
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| 摘 要： | 目的 制备利福平脂质体温敏型原位凝胶，并对其体外性质进行研究。方法 采用薄膜分散法制备利福平脂质体，并对利福平脂质体进行表征研究；以泊洛沙姆188、泊洛沙姆407为凝胶基质，制备利福平脂质体温敏型原位凝胶；以无膜溶出模型研究温敏型原位凝胶体外累积溶蚀率；采用透析袋法分析药物体外释放情况。结果 制备的利福平脂质体平均粒径、聚分散指数、Zeta电位、包封率和载药量分别为(149.0±5.67)nm、0.275±0.056、-(29.8±1.59)mv、(79.6±2.67)%，(18.6±0.25)%；利福平脂质体温敏型原位凝胶的胶凝温度为(34.3±0.6)℃。体外溶蚀曲线和体外释药曲线均符合零级动力学特征。结论 利福平脂质体温敏型原位凝胶的制备工艺简单易行，体外释放显示其有很好的缓释作用。
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| 关 键 词： | 利福平 脂质体 温敏型原位凝胶 溶蚀 |
| 收稿时间： | 2015/5/21 0:00:00 |
| 修稿时间： | 2016/1/18 0:00:00 |
Preparation of Rifampicin Liposomes in Situ Gel System and Its in Vitro Release Mechanism |
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| CAO Jiawei,NI Jianjun,YAO Jun,ZHOU Feng,ZHOU Zhongyuan,XU Yingying and CAI Xinjun.Preparation of Rifampicin Liposomes in Situ Gel System and Its in Vitro Release Mechanism[J].The Chinese Journal of Modern Applied Pharmacy,2016,33(2):183-187. |
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| Authors: | CAO Jiawei NI Jianjun YAO Jun ZHOU Feng ZHOU Zhongyuan XU Yingying and CAI Xinjun |
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| Affiliation: | Department of Pharmacy, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou 310003, China,Department of Pharmacy, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou 310003, China,Department of Pharmacy, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou 310003, China,Department of Pharmacy, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou 310003, China,Department of Pharmacy, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou 310003, China,Department of Pharmacy, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou 310003, China and Department of Pharmacy, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou 310003, China |
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| Abstract: | |
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| Keywords: | rifampicin liposomes in situ gel system erosion |
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