地诺前列酮栓用于足月引产的临床评价

目的：研究地诺前列酮栓（欣普贝生）用于足月引产的有效性及安全性。方法：选取140例有引产指征的单胎初产妇，按照随机数字表法分为研究组（欣普贝生治疗组）64例和对照组（缩宫素治疗组）76例。比较两组孕妇用药后促宫颈成熟有效率、引产效果、分娩情况、新生儿情况及不良反应。结果：研究组促宫颈成熟的总有效率为93.75%，对照组为75.00%，两组比较差异有统计学意义（P〈0.01）。从开始用药至临产的时间研究组显著短于对照组，两组比较差异有统计学意义（P〈0.05）。研究组的阴道分娩率为70.31%，对照组为47.37%，两组比较差异有统计学意义（P〈0.05）。两组产后出血量和新生儿窒息率比较差异均无统计学意义（P〉0.05）。欣普贝生的主要副作用是子宫过度刺激，发生率为3.12%。结论：地诺前列酮栓（欣普贝生）促宫颈成熟效果优于缩宫素，可安全、有效地用于足月引产。

The Clinical Evaluation on Dinoprostone for Induction of Term Pregnancy

Objective：To explore the effect and safety of dinoprostone on induction of term pregnancy. Method：One hundred and forty single births primipara with indications for induction of labor were randomly divided into two groups：the study group（64 cases,treated with dinoprostone）and the control group（76 cases,treated with oxytocin）. The overall rate of cervical ripening,medication effects,vaginal delivery,neonatal outcome and adverse reaction between the two groups were compared. Result：The total effective rate of promoting cervical ripening in study group was 93.75%,significantly higher than 75.00%of control group（P〈0.01）.The time from medication to parturition in study group was significantly shorter than the control group（P〈0.05）. Vaginal delivery rate in study group was 70.31%,while which in control group was only 47.37%, the difference was statistically significant（P〈0.05）.There were no significant differences in postpartum hemorrhage and neonatal asphyxia rate between two groups. The major side effect of dinoprostone was uterine hyperstimulation and the incidence in study group was 3.12%. Conclusion：Dinoprostone is more effective than oxytocin in cervical ripening,and can be used for induction of term pregnancy effectively and safely.