| 载药淀粉微球的合成研究 |
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| 引用本文： | 詹国平,黄可龙,张法旺.载药淀粉微球的合成研究[J].化学世界,2005,46(12):726-728,721. |
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| 作者姓名： | 詹国平 黄可龙 张法旺 |
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| 作者单位： | 中南大学化学化工学院,湖南,长沙,410083;中南大学化学化工学院,湖南,长沙,410083;中南大学化学化工学院,湖南,长沙,410083 |
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| 摘 要： | 以可溶性淀粉为原料，环氧氯丙烷为交联剂，Span60为乳化剂，甲苯和蓖麻油的混合物为油相，采用逆相悬浮交联聚合法合成淀粉微球。实验运用正交优化设计，选择淀粉浓度、油水相之比、乳化剂用量和交联剂用量四个因素为考察对象，对淀粉微球的制备条件进行了优化。利用红外（IR）、扫描电镜（SEM）、激光粒度分析仪（LPA）等对产物进行了表征。
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| 关 键 词： | 可溶性淀粉 逆相悬浮交联聚合 微球 表征 |
| 文章编号： | 0367-6358（2005）12-726-03 |
| 收稿时间： | 2004-12-21 |
| 修稿时间： | 2004-12-212005-09-13 |
Synthesis of Starch Microspheres as Drug Carriers |
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| ZHAN Guo-ping,HUANG Ke-long,ZHANG Fa-wang.Synthesis of Starch Microspheres as Drug Carriers[J].Chemical World,2005,46(12):726-728,721. |
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| Authors: | ZHAN Guo-ping HUANG Ke-long ZHANG Fa-wang |
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| Affiliation: | School of Chemistry and Chemical Engineering, Central South University, Hunan Changsha 410083, China |
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| Abstract: | The neutral starch microspheres(ESM)were synthesized from soluble starch by counter suspension crosslinking polymerization with epichlorohydrin as the crosslinking agent,span 60 as the emulsifying agent and the mixture of toluene and castor oil as the organic phase.With the concentration of starch,ratio of organic phase and aqueous phase,the quantity of emulsifying agent and cross-linking agent chosen as considering parameters,the preparation conditions were optimized.The product was characterized by IR,SEM and LPA. |
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| Keywords: | soluble starch counter suspension crosslinking polymerization microsphere characterization |
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