核转录因子κB与肌细胞的生长和运动

以往核转录因子κB的研究多限于免疫细胞,而近年来,核转录因子κB在肌细胞的研究方面备受关注.核转录因子KB的靶基因编码不同的功能蛋白,藉此,核转录因子κB既能诱发炎症加剧、蛋白降解、组织损伤,也能促进细胞生长和维持.核转录因子κB阻断剂的阻断作用与其氧化性无关.运动会激活核转录因子κB,此时,核转录因子κB的作用可能与其在病理性条件下的作用不同,是促进细胞生长发育的.文章总结并分析核转录因子κB对细胞生长的作用,及运动介导下骨骼肌中核转录因子κB的变化趋势和影响,为肌肉康复及运动适应性变化的研究提供依据.

Growth and movement of nuclear factor kappa B and muscle cells

Most previous researches on nuclear factor κB (NFκB) are limited to immune cells. Recently, however, researches on NFKB in muscle cells attract more attention. Target genes of NFκB encodes proteins with different functions, accordingly NFκB can not only induce inflammation deterioration, protein degradation and tissue injury but also promote cell growth and maintenance. But the inhibitation effect of NFκB inhibitors is not related with its antioxidant capacity. Exercise can activate NFκB during which process NFκB may act as an inducer of cell growth and development which is different from its role under pathological situation. This article sums up and analyzes the effect of NFκB on cell growth, the changing trend and effect of NFκB in skeletal muscle under exercise, providing data for the researches on muscle rehabilitation and motion fitness change.