| 阵发性睡眠性血红蛋白尿患者测定CD55、CD59的意义 |
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| 引用本文： | 邱国强,谢晓宝,吴浩清,许文荣!,曹红翠!,胡嘉波!.阵发性睡眠性血红蛋白尿患者测定CD55、CD59的意义[J].江苏大学学报(医学版),1999(1). |
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| 作者姓名： | 邱国强 谢晓宝 吴浩清 许文荣! 曹红翠! 胡嘉波! |
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| 作者单位： | 常州市第一人民医院血液病实验室!213003，常州市第一人民医院血液病实验室!213003，常州市第一人民医院血液病实验室!213003 |
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| 摘 要： | 本文采用流式细胞技术测定6例阵发性睡眠性血红蛋白尿（PNH）．11例再障-PNH综合征，10例再生障碍性贫血（AA）患者外周血淋巴细胞膜CD55和CD59标记率。6例PNH患者均表现出CD55和CD59下降（P＜0.01）．11例再障-PNH综合征患者也表现出CD55和CD59下降（P＜0.05）。10例再生障碍性贫血患者中8例CD55和CD59标记率在95％以上．2例标记率在85％以上，与对照组相比无统计学意义。结果表明：血细胞膜上糖基磷脂酰肌醇（GPI）“锚”相关蛋白CD55和CD59的缺陷与PNH有密切关系。流式细胞技术测定血细胞膜CD55和CD59可作为诊断PNH的有效方法。
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| 关 键 词： | 阵发性睡眠性血红蛋白尿 流式细胞术 CD55 CD59 |
Study on Clinical Significance of Detection of CD55 and CD59 in Patients With Paroxysmal Nocturnal Haemoglobinuria(PNH) |
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| Qiu Guoqiang, Xie Xiaobao.Study on Clinical Significance of Detection of CD55 and CD59 in Patients With Paroxysmal Nocturnal Haemoglobinuria(PNH)[J].Journal of Jiangsu University Medicine Edition,1999(1). |
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| Authors: | Qiu Guoqiang Xie Xiaobao |
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| Affiliation: | Qiu Guoqiang; Xie Xiaobao(Laboratory of hematology in changZhou No.1 people's Hospital)Xu wenrong; Cao hongcui(Department of hematology in Zhen Jiang Medical College) |
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| Abstract: | Six cases of paroxysmal noctural haemoglobinuria (PNH). eleven cases of aplastic anaemia(AA-PNH)syndrome and ten cases of aplastic anemid (AA) were investigated by Flow Cytometry for exprpssion of CD55 and CD59 on periferal blood lymphocyte. The results showed that the exprpssion of CD55and CD59 in patients with PNH (6 cases) and patients with AA-PNH (11 cases) decreased respectively (P<0. 01, P<0. 05). In contrast, the expression of CD55 and CD59 in patients with AA (10 cases) did not declinemarkedly (P>0.05). It was demonstrated that PNH was related with a deficiency of glycosylphatidylinositol(GPI) -anchor protein CD55 and CD59. It was suggested that assay for present of CD55 and CD59 on periferalblood lymphocyte with Flow cytometry was a useful method for PNH diagnosis. |
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| Keywords: | PNH CD55 CD59 Fow Cytometry |
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