急性脑梗死患者的血清瘦素与IL-6水平变化的临床意义

目的:探讨急性脑梗死患者血清瘦素、IL-6水平变化的发生机制及其与预后的关系。方法:本院经CT或MRI确诊的急性脑梗死患者40例,男24例,女16例;年龄41岁~79岁;入院后于48h内(急性期)、第7天(亚急性期)、第21天(恢复期)分别抽取空腹静脉血,用酶联免疫分析法(ELISA)检测血清瘦素、IL-6的水平,同时检测对照组30例健康成年人血清瘦素、IL-6水平。结果:急性脑梗死患者组急性期、亚急性期、瘦素、IL-6水平均与对照组差异有显著性,而恢复期瘦素、IL-6水平与对照组差异无显著性。结论:急性脑梗死患者存在高瘦素,其水平随着患者的康复而逐渐恢复正常。

Clinical Significance of the Changes of Serum Serum Leptin and IL-6 Levels

Objective To study the occurrence mechanism of the changes of serum leptin and IL-6 levels in acute cerebral infarction patients and it's relation with prognosis. Methods 40 patients(24 males,16 females)confirmed by CT were studied with their ages ranging from 41 to 79. Fasting venous blood was withdrawn within first 48hs(acute stage),and on the 7th day(subacute stage), and on the 21st day(recovery stage)after admission. Both blood serum leptin and IL-6 were detected with ELISA.30 healthy adults were detected Simultaneously as control group.Resutls The level of serum leptin and IL-6 of acute cerebral infarction group in acute stage and subacute stage have significance difference with the control group(P<0.01),but it has no significance difference between the patients in recovery stage and the control group(P>0.05). Conclution There are hyperleptinemis in acute cerebral infarction patients,and the level of them restoreto the normal along with the recovery of patients.