宁波市肺结核病药物耐药监测报告

目的 建立以WHO指南为基础的结核病细菌学耐药监测系统，掌握宁波市初始和获得性耐药水平。方法 采用整群抽样方法于1999年10月至2000年3月选择全市所有新发涂阳病例（包括复治涂阳病例），并对其全部培养阳性的菌株进行菌型鉴定及4种抗结核药物（INH，SM、RFP、EMB）的耐药测试。结果 总耐药率为22.44%，初始耐药率为17.87%，初始耐多药率为3.40%。获得性耐药率为78.95%。获得性耐多药率为42.11%。结论 宁波市结核病的初始耐药率处于较高水平，须进一步加强全市的结核病控制工作。

A Surveillance Report on the Drug-resistant Tuberculosis in Ningbo of Zhejiang Province

Objective To establish the surveillance system for drug resistance of tuberculosis according to WHO guideline and to evaluate the initial and acquired drug resistance in Ningbo. Methods Cluster sampling technique was applied to continuously select all the patients with smear posntive pulmonary tuberculosis from October 1999 to March 2000. Identification and susceptibility tests were conducted in all culture positive samples.Results The total frequency of drug resistance was 22.44%, initial drug resistance 17.87%, initial multi - drug resistance 3.40%, acquired drug resistance 78.95%, and acquired multi - drug resistance 42.11%. Conclusions The results showed that the initial drug resistance ranks high in Ningbo of Zhejiang province, and the Tuberculosis Control Program of Ningbo should be further strengthened.