| 非诺贝特酸的相转移催化合成 |
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| 引用本文： | 李敢,王德堂,时光侠,刘颖,肖先举,夏先伟.非诺贝特酸的相转移催化合成[J].广州化工,2014(21):102-104. |
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| 作者姓名： | 李敢 王德堂 时光侠 刘颖 肖先举 夏先伟 |
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| 作者单位： | 1. 徐州工业职业技术学院化学工程技术学院，江苏 徐州 221140; 江苏省化工新材料工程技术研究开发中心，江苏 徐州 221140
2. 徐州工业职业技术学院化学工程技术学院,江苏 徐州,221140 |
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| 摘 要： | 以4-羟基-4＇-氯二苯甲酮和氯仿为原料,TEBA为催化剂,在氢氧化钾水溶液存在的条件下合成了非诺贝特酸。考察了氢氧化钾溶液浓度、催化剂用量、滴加氯仿温度和氯仿用量等因素对非诺贝特酸产率的影响。确定最佳反应条件为：4-羟基-4＇-氯二苯甲酮30 g,丙酮120 g,氯仿40 g,TEBA 2.5 g,氢氧化钾水溶液浓度50%,反应温度30℃,产率可达89.7%。
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| 关 键 词： | 非诺贝特酸 相转移催化 合成 |
Synthesis of Fenofibrate Acid by Phase Transfer Catalysis |
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| LI Gan,WANG De-tang,SHI Gang-xia,LIU Ying,Xiao Xian-ju,XIA Xian-wei.Synthesis of Fenofibrate Acid by Phase Transfer Catalysis[J].GuangZhou Chemical Industry and Technology,2014(21):102-104. |
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| Authors: | LI Gan WANG De-tang SHI Gang-xia LIU Ying Xiao Xian-ju XIA Xian-wei |
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| Affiliation: | LI Gan;WANG De-tang;SHI Gang-xia;LIU Ying;Xiao Xian-ju;XIA Xian-wei;Xuzhou College of Industrial Technology,Chemical Engineering Institure;Jiangsu Province Engineering Technolog Research and Development Center of New Chemical Material; |
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| Abstract: | TEBA was used as phase-transfer catalyst to synthesize Fenofibrate acid from 4-hydroxy-4＇-chlorobenzophenone and chloroform in water solution of potassium hydroxide with acetone as solvent. The effects of factors such as the concentration of water solution of potassium hydroxide,the catalyst of TEBA,the reaction temperature and the catalyst of chloroform on the yield were examined. The optimal reaction conditions determined were that 4-hydroxy-4＇-chlorobenzophenone catalyst was 30 g,acetone catalyst was 120 g,chloroform catalyst was 40 g,TEBA catalyst was2. 5 g,the concentration of water solution of potassium hydroxide was 50%,reaction temperature was 30 ℃,and the yield reached 89. 7%. |
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| Keywords: | Fenofibrate acid catalysis synthesis |
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