| 聚合胶束载药多柔比星的研究进展 |
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| 引用本文： | 许向阳,李玲,周建平.聚合胶束载药多柔比星的研究进展[J].中国新药杂志,2007,16(1):28-32. |
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| 作者姓名： | 许向阳 李玲 周建平 |
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| 作者单位： | 1. 江苏先声药物研究有限公司,南京,210042;中国药科大学药剂教研室,南京,210009
2. 中国药科大学药剂教研室,南京,210009 |
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| 摘 要： | 多柔比星（阿霉素，adriamycin）是临床上广泛使用的抗癌药，但其对正常组织的毒性和固有的多药耐药性是急需解决的问题。聚合胶束作为抗癌药的载体具有靶向作用，可减少毒副作用，提高抗癌药物的化疗指数。现对国外聚合胶束载药阿霉素的制备、理化性质、体外释放、生物学分布、抗肿瘤活性及靶向性进行综述。
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| 关 键 词： | 多柔比星(阿霉素) 聚合胶束 靶向性 |
| 文章编号： | 1003-3734（2007）01-0028-05 |
| 收稿时间： | 2006-08-10 |
| 修稿时间： | 2006-08-10 |
Advances on the research of doxorubicin loaded polymeric micelles |
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| XU Xiang-yang,LI Ling,ZHOU Jian-ping.Advances on the research of doxorubicin loaded polymeric micelles[J].Chinese Journal of New Drugs,2007,16(1):28-32. |
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| Authors: | XU Xiang-yang LI Ling ZHOU Jian-ping |
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| Abstract: | Doxorubicin widely used as anticancer agent has disadvantages due to the cytotoxicities to normal tissues and multi-drug resistance. Polymeric micelles used as anticancer drug carriers show a few advantages in the improvement of drug-targeted release and chemotherapeutic efficacy, and the reduction of toxic effects of doxorubicin. This paper presents the preparation, characterization, in vitro release, biodistribution, improved anti-tumor activities and targeted deliver of doxorubicin loaded polymeric micelles. |
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| Keywords: | doxorubicin polymeric micelles target |
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