| 三阴性乳腺癌的研究进展 |
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| 引用本文： | 顾军,于泽平,李宁.三阴性乳腺癌的研究进展[J].医学研究生学报,2010,23(1):105-109. |
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| 作者姓名： | 顾军 于泽平 李宁 |
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| 作者单位： | 南京军区南京总医院普通外科,南京,210002 |
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| 基金项目： | 南京军区南京总医院科研基金(2005045) |
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| 摘 要： | 三阴性乳腺癌（triple negative breastcancer，TNBC）是指雌激素受体（estrogen receptor，ER）、孕激素受体（progesterone receptor，PR）与人类表皮生长因子受体2（human epidermal growth factor receptor—type2，Her-2）均为阴性的一类乳腺癌，其具有侵袭性生物学行为及临床病理特，征的一个乳腺癌亚型，与基底细胞样乳腺癌和乳腺癌易感癌基因1（breast cancer susceptibitity genel，BRCAI）相关性乳腺癌有一定相关性。此类型乳腺癌对常规标准治疗效果欠佳，易发生远处转移，预后较其他类型乳腺癌差。对TNBC的深入研究，将有助于人们采取有效的治疗方法来提高其疗效。
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| 关 键 词： | 三阴性乳腺癌 基底细胞样乳腺癌 乳腺癌易感癌基因 预后 治疗 |
Progress in the study of triple negative breast cancer |
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| GU Jun,YU Ze-ping,LI Ning.Progress in the study of triple negative breast cancer[J].Bulletin of Medical Postgraduate,2010,23(1):105-109. |
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| Authors: | GU Jun YU Ze-ping LI Ning |
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| Affiliation: | Department of general surgery;Nanjing General Hospital of Nanjing Military Command;PLA;Nanjing 210002;Jiangsu;China |
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| Abstract: | Triple-negative breast cancer (TNBC) is a subgroup of breast cancers defined by a lack of the expressions of estrogen,progesterone and HER2 receptors,with more aggressive biological and clinicopathological characteristics and a close relationship with basal-like and breast cancer susceptibility gene-1 (BRCA1)-related breast cancers.TNBC is insensitive to most available hormonal or standard therapeutic agents,associated with increased risk for distant metastases and with poorer prognosis than other types of ... |
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| Keywords: | Triple negative breast cancer Basal-like breast cancer Breast cancer susceptibility gene Prognosis Therapy |
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