血清α1-抗胰蛋白酶和C反应蛋白水平与慢性阻塞性肺疾病的相关性研究

目的探讨慢性阻塞性肺疾病（COPD）患者血清c反应蛋白（CRP）和α1-抗胰蛋白酶（α1-AT）水平与COPD严重程度的相关性。方法采用免疫比浊法测定43例COPD急性加重期（AECOPD）患者、47例COPD稳定期患者及40名健康体检者（正常对照组）血清CRP和α1-AT水平，并作统计学分析。结果血清CRP和α1-AT水平均随患者病情加重而呈上升趋势；AECOPD组和COPD稳定期组CRP和α1-AT水平均高于正常对照组（P〈0．01）；AECOPD组CRP和α1-AT水平均高于COPD稳定期组（P〈0．05）。AECOPD组患者血清CRP与α1-AT呈正相关（r=0．704，P〈0．01），而COPD稳定期组血清CRP与α1-AT水平无相关关系（r=0．232，P〉0．05）。结论COP]）患者气道炎症反应持续存在，CRP和α1-AT是COPD患者病情变化的敏感指标，且与气道的炎症程度呈正相关，AECOPD的CRP敏感性优于α1-AT，而α1-AT水平在COPD病情加重时并没有明显的升高。

Correlationship of serum alphal-antitrypsin and C reactive protein levels with chronic obstructive pulmonary disease

Objective To investigate serum C reactive protein （CRP） and alpha1-antitrypsin （α1-AT） levels in patients with chronic obstructive pulmonary disease（COPD） and the correlation with the severity of COPD. Methods Serum levels of CRP and α1-AT were determined by immunoturbidimetry in 43 patients with acute exacerbation chronic obstructive pulmonary disease （AECOPD）, 47 patients with stable COPD and 40 healthy subjects （healthy control group） ,and the results were analyzed statistically. Results Serum levels of CRP and α1-AT had emerge rise trend with the severity of disease. Serum levels of CRP and α1-AT in AECOPD group and stable COPD group were higher than those in healthy control group（ P 〈 0.01 ） . Serum levels of CRP and α1-AT in AECOPD group were higher than those in stable COPD group（P 〈0.05）. Serum level of CRP was correlated positively with serum level of α1-AT in AECOPD group （r =0. 704 ,P 〈0.01 ）. However, serum level of CRP was uncorrelated with serum level of α1-AT in stable COPD group （r =0. 232,P 〉 0.05 ）. Conclusions The airway inflammation is continuously existing in patients with COPD. CRP and α1-AT are sensitive indicators for the patients with COPD, and are positively con＇elated with the severity of airway inflammation. CRP is more sensitive than α1-AT for AECOPD patients, and there is no obvious inereasing of α1-AT level.