心脉隆注射液静脉泵入对脓毒血症并心力衰竭患者血清心肌损伤标志物和血清炎症因子水平的影响

目的观察心脉隆注射液静脉泵入对脓毒血症并心力衰竭患者血清心肌损伤标志物水平和血清炎症因子水平的影响。方法选取2015年12月—2017年11月在保定市第一中心医院治疗的100例脓毒血症合并心力衰竭患者,按照随机数字表法分为对照组和观察组,每组50例。对照组给予西药规范基础治疗,观察组在对照组治疗方法基础上加用心脉隆注射液静脉泵入治疗。治疗7 d后,观察2组治疗前后心肌损伤标记物肌酸磷酸激酶(CK)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)]、APACHEⅡ评分、血清炎症因子降钙素原(PCT)、B型钠尿肽(BNP)、氨基末端脑钠肽前体(NT-proBNP)]的改善情况,并评估临床疗效。结果对照组总有效率为76%(38/50),低于观察组的94%(47/50)(P<0.05);治疗后2组CK、LDH、CK-MB、PCT、BNP、NT-proBNP水平均降低,且观察组以上各指标均低于对照组,差异均具有统计学意义(P均<0.05);2组治疗3 d和7 d后APACHEⅡ评分均不断降低,且观察组均低于对照组,差异均有统计学意义(P均<0.05)。结论心脉隆注射液能够有效抑制脓毒血症并心力衰竭患者心肌损伤,减轻炎性反应,改善患者病理生理状态。

Effects of intravenous pumping of Xinmailong injection on levels of serum myocardial injury markers and serum inflammatory factors in patients with sepsis and heart failure

Objective It is to observe the effects of intravenous pumping of Xinmailong injection on levels of serum myocardial injury markers and serum inflammatory factors in patients with sepsis and heart failure.Methods A total of 100 patients with sepsis and heart failure who were treated in Baoding First Central Hospital from December 2015 to November 2017 were selected and divided into control group and observation group according to the random number table method,with 50 cases in each group.The control group was given western medicine standard basic treatment,and the observation group was treated with Xinmailong injection by intravenous pump based on the treatment method of the control group.After 7 days of treatment,the improvements of the myocardial injury markerscreatine phosphate kinase(CK),lactate dehydrogenase(LDH),creatine kinase isoenzyme-MB(CK-MB)],APACHEⅡscore,and serum inflammation factorsprocalcitonin(PCT),B-type natriuretic peptide(BNP),amino-terminal brain natriuretic peptide precursor(NT-proBNP)]after treatment were observed in the two groups,and the clinical efficacy was evaluated.Results The total effective rate in the control group was 76.0%(38/50),which was lower than 94.0%(47/50)in the observation group(P<0.05).After treatment,the levels of CK,LDH,CK-MB,PCT,BNP,and NT-proBNP were significantly decreased in both groups,and the decreases were more significant in the observation group than those in the control group,the differences were statistically significant(P<0.05);the APACHEⅡscores were continuously decreased on both 3d and 7d of treatment in the two groups(P<0.05),and the scores in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Xinmailong injection can effectively inhibit myocardial injury,relieve inflammatory reaction and improve the pathophysiology in patients with sepsis and heart failure.