| 胶质瘤中FGFR1OP和PTEN的表达及临床意义 |
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| 引用本文： | 谭永刚,王浩,邹华伟.胶质瘤中FGFR1OP和PTEN的表达及临床意义[J].微生物学杂志,2009,29(2):109-112. |
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| 作者姓名： | 谭永刚 王浩 邹华伟 |
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| 作者单位： | 1. 中国医科大学,附属盛京医院第一肿瘤科,辽宁,沈阳,110004
2. 北京通州区潞河医院,神经外科,北京,100000 |
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| 摘 要： | 探讨FCFR1OP和PTEN在胶质瘤中的表达情况和临床意义。选取54例胶质瘤手术切除标本，采用SP法进行免疫组织化学染色。FGFR1OP和PTEN的阳性表达率分别为85．2％和48．1％，且随着胶质瘤的恶性程度不同表现出明显的统计学差异（P〈0．05）。FGFR1OP的高表达与PTEN的低表达可能参与胶质瘤的生长分化和进展，并提示预后不良。
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| 关 键 词： | 胶质瘤 FGFR1OP PTEN |
FGFR1OP and PTEN Display Biological and Clinical Significance in the Development of Gliomas |
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| TAN Yong-gang,WANG Hao,ZOU Hua-wei.FGFR1OP and PTEN Display Biological and Clinical Significance in the Development of Gliomas[J].Journal of Microbiology,2009,29(2):109-112. |
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| Authors: | TAN Yong-gang WANG Hao ZOU Hua-wei |
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| Affiliation: | TAN Yong-gang, WANG Hao , ZOU Hua-wei ( 1. Department of oncology, Shengjing hospital, China Medical University, Shenyang, 110004, China; 2. Department of neurosurgery, Luhe Hospital, Tongzhou District, Beijing, 100046, China) |
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| Abstract: | Our subject is to determine the clinical significance of FGFR1OP and PTEN expression levels in glioma. By using SP immunohistochemical method, FGFR1OP and PTEN in biopsy specimens from 54 glioma patients were examined. The results displayed 66.7% positive rate for FGFR1OP while 48.1% positive rate for PTEN. And glio-mas with different malignant degrees showed distinct expression levels of FGFR1OP and PTEN with statistically signifi-cant differences (P<0.05). The high FGFR1OP and lower PTEN expressions were probably involved in differentia-tion and development of glioma and implyed unfavourable prognosis. |
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| Keywords: | FGFR1OP PTEN Glioma FGFR1OP PTEN |
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