膀胱移行细胞癌患者尿Survivin及透明质酸含量检测意义

目的:探讨尿survivin含量及尿液透明质酸含量检测在膀胱癌诊断及预后中的价值。方法:本实验观察对象为膀胱癌患者87例、其他疾病患者40例及30例健康成人。收集各组尿液,采用ELISA法行survivin、透明质酸含量检测。结果:膀胱癌组survivin含量为(2.51±1.91)μg/L,其他疾病组为(0.55±0.22)μg/L,正常对照组(0.40±0.17)μg/L。膀胱癌组尿液透明质酸含量为(3.12±0.69)mmol/L,其他疾病组为(1.41±0.46)mmol/L,正常对照组为(1.24±0.35)mmol/L。结论:联合检测尿survivin含量和透明质酸含量可作为膀胱癌无创诊断及预后判断辅助方法。

Expression of survivin and hyaluronic acid levels in urine of the patients with bladder transitional cell carcinoma

Objective To study the clinical significance in survivin and hyaluronic acid level detection in urine in patients with bladder transitional cell carcinoma.Methods Eighty-seven patients with bladder transitional cell carcinoma,40 patients with other diseases and 20 healthy persons were included in this experiment.The levels of survivin and hyaluronic acid were determined with ELISA.Results The levels of survivin and hyaluronic acid in bladder transitional cell carcinoma group were significant higher than the other groups and the contents of survivin and hyaluronic acid increased with tumor grade and stage progression.Conclusion The detection of hyaluronic acid and survivin levels of urine is an effective auxiliary method in the diagnosis and prognosis of bladder transitional cell carcinoma.