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Corticosteroids and cellulose purification improve,respectively, the in vivo translation and vaccination efficacy of sa-mRNAs
Authors:Zifu Zhong  Séan McCafferty  Lisa Opsomer  Haixiu Wang  Hanne Huysmans  Joyca De Temmerman  Stefan Lienenklaus  João Paulo Portela Catani  Francis Combes  Niek N Sanders
Affiliation:1. Laboratory of Gene Therapy, Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium;2. Cancer Research Institute (CRIG), Ghent University, 9000 Ghent, Belgium;3. Laboratory of Immunology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;4. Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium;5. Institute for Laboratory Animal Science, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
Abstract:
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  • Keywords:innate immunity inhibitors  self-amplifying mRNA  type I IFN  mRNA purification  cellulose  clobetasol  Zika vaccine
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