熔体静电纺丝直写技术在组织工程中的应用进展

熔体静电纺丝直写技术以其纤维直径、沉积形貌可控性高及无溶剂残留等优势，为高强度复杂形貌可控仿生组织工程（TE）支架的制备提供了巨大的空间，成为近年来的研究热点。本文首先简述了熔体静电纺丝直写技术相对于各类其他TE支架制备方法的优势；其次从工艺调控方面综述了熔体静电纺丝直写技术的工艺研究进展，并总结了实现复杂可控形貌TE支架的调控方法；随后从支架材料、形貌表征和细胞培养效果等方面综述了熔体静电纺丝直写技术的TE应用进展，并概括了该技术制备的TE拓扑结构支架的种类及特点；最后指出熔体静电纺丝直写技术具有广阔的研究前景，且该技术应以制备仿生、材料多样化以及复合支架为研究重点。

Progress in melt electrospinning direct writing technology intissue engineering

The melt electrospinning direct writing technology provides a huge space for the preparation of high-strength complex morphology controllable biomimetic tissue engineering (TE) scaffolds due to its high controllability of fiber diameter and deposition morphology, solvent-free residue and other advantages. It has become a research hotspot in recent years. First, this paper briefly describes the advantages of melt electrospinning direct writing technology over various other TE scaffold preparation methods; secondly, the process research progress of melt electrospinning direct writing technology is reviewed from the aspects of process regulation, and the control methods for implementing complex controllable topography TE scaffold are summarized; then the progress of TE application of melt electrospinning direct writing technology is reviewed from the aspects of scaffold materials, morphological characterization and cell culture effects, in addition, the types and characteristics of TE topological structure scaffolds prepared by this technology are summarized; finally, it is pointed out that the melt electrospinning direct writing technology has broad research prospects, and the technology should focus on the preparation of bionics, material diversification and composite scaffolds.