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Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy?
Authors:Oana Baru  Andreea Nutu  Cornelia Braicu  Cosmin Andrei Cismaru  Ioana Berindan-Neagoe  Smaranda Buduru  Mîndra Badea
Abstract:Angiogenesis is a broad spread term of high interest in regenerative medicine and tissue engineering including the dental field. In the last two decades, researchers worldwide struggled to find the best ways to accelerate healing, stimulate soft, and hard tissue remodeling. Stem cells, growth factors, pathways, signals, receptors, genetics are just a few words that describe this area in medicine. Dental implants, bone and soft tissue regeneration using autologous grafts, or xenografts, allografts, their integration and acceptance rely on their material properties. However, the host response, through its vascularization, plays a significant role. The present paper aims to analyze and organize the latest information about the available dental stem cells, the types of growth factors with pro-angiogenic effect and the possible therapeutic effect of enhanced angiogenesis in regenerative dentistry.
Keywords:angiogenesis  mesenchymal stem cells  dental stem cells  tissue regeneration  dental implants
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