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| 氯代甲酸异丙酯含量的测定方法研究 | |
| 引用本文： | 王云清,赵韵琪,段惠敏,王云芝,刘玉英.氯代甲酸异丙酯含量的测定方法研究[J].河北科技大学学报,2001,22(2):32-34,55. |
| 作者姓名： | 王云清 赵韵琪 段惠敏 王云芝 刘玉英 |
| 作者单位： | 1. 河北科技大学理学院, 2. 天津市达仁堂制药二厂, 3. 衡水技术监督检验所, |
| 摘 要： | 建立了一种测定氯代甲酸异丙酯含量的新方法。用 Volhard法预先将酯中水解性 (无机 )氯沉淀下来 ,然后在溶液中加入 40 m L碱性吡啶乙醇溶液 ,在震荡频率为 6 0次 / min的条件下使酯中有效氯全部转化成无机氯 ,反滴定由氯代甲酸异丙酯中有效氯转化的无机氯离子 ,间接求得酯含量。该法直接用于产品测定 ,标准偏差≤ 0 .0 9% ,变异系数≤ 0 .1 %。 |
| 关 键 词： | 氯代甲酸异丙酯 生产控制 质量检验 测定方法 |
| 文章编号： | 1008-1542(2001)02-0032-03 |
| 修稿时间： | 2000年12月14 |
Determination of Isopropyl Chloroformate |
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| WANG Yun qing ,ZHAO Yun qi ,DUAN Hui min ,WANG Yun zhi ,LIU Yu ying.Determination of Isopropyl Chloroformate[J].Journal of Hebei University of Science and Technology,2001,22(2):32-34,55. | |
| Authors: | WANG Yun qing ZHAO Yun qi DUAN Hui min WANG Yun zhi LIU Yu ying |
| Affiliation: | WANG Yun qing 1,ZHAO Yun qi 1,DUAN Hui min 1,WANG Yun zhi 2,LIU Yu ying 3 |
| Abstract: | A new method for the determination of isopropyl chloroformate is proposed.The hydrolyzed or inorganic chlorine ion in the isopropyl chloroformate sample solution is first completely precipitated with silver nitrate according to the volhard procedure for the purpose of eliminating its interference with the subsequent determination.Then 40 mL alkaline ethanol solution of pyridine is added to the solution to convert the component chlorine of isopropyl chloroformate into inorganic chlorine ion with shaking at a frequence of 60/min.The chlorine ion thus produced is precipitated again by adding silver nirrage soluton.Finally,the isopropyl chloroformate content in samples is determined by following back titration of the excessive silver nitrate,the result being with a standard deviation equal to or less than 0.095 and a coefficient ≤0.1%. |
| Keywords: | isopropyl chloroformate production control duction quality test analytical method |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
