不同剂量长效曲普瑞林在体外受精-胚胎移植中应用的比较

目的:探讨体外受精-胚胎移植(IVF-ET)中不同剂量促性腺激素释放激素激动剂(GnRH-a)垂体降调节对临床结局的影响。方法:回顾性分析长效曲普瑞林1.0 mg和1.2 mg两种剂量降调节的治疗效果。结果:两种剂量长效曲普瑞林降调节后,血卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)水平比较差异无统计学意义(P>0.05);两组促性腺激素(Gn)使用时间、Gn总用量、穿刺卵泡数、获卵率、受精率、卵裂率、优质胚胎率、临床妊娠率、种植率、卵巢过度刺激综合征(OHSS)发生率比较均无显著差异(P>0.05)。结论:长效曲普瑞林1.0 mg和1.2 mg均可获得满意的垂体降调节效果和IVF结局,建议在达到同样效果的前提下尽量减少GnRH-a的用量。

Comparison of the applications of different doses of long-acting Triptorelin in in vitro fertilization-embryo transfer

Objective:To explore the effects of pituitary down-regulation with different doses of gonadotrophin releasing hormone agonist(GnRH-a) on clinical outcome of in vitro fertilization-embryo transfer(IVF-ET).Methods:The curative effects of two kinds doses(1.0 mg and 1.2 mg) of long-acting Triptorelin for down-regulation were analyzed retrospectively.Results:After down-regulation with two kinds doses of long-acting Triptorelin,there was no significant difference in the levels of serum follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol,and progesterone between the two groups(P>0.05);there was no significant difference in the administration time of gonadotropin,the total dose of gonadotropin,the number of follicles punched,the number of oocytes retrieved,the fertilization rate,the cleavage rate,the rate of high quality embryos,the clinical pregnancy rate,the implantation rate,and the incidence of ovarian hyperstimulation syndrome(OHSS) between the two groups(P>0.05).Conclusion:Both 1.0 mg long-acting Triptorelin and 1.2 mg long-acting Triptorelin can obtain satisfactory pituitary down-regulation effect and IVF outcome,it is recommended to reduce the dose of GnRH-a under the circumstance of getting the same effect.