黄芩苷分散片的制备及其溶出度测定

目的：考察黄芩苷固体分散体片剂的制备与溶出度测定。方法：采用研磨法将辅料和黄芩苷混匀制成分散体,直接压片法制备黄芩苷分散片,利用高效液相色谱（HPLC）测定其溶出度。结果：黄芩苷质量浓度在10～100μ/mL的范围内,质量浓度与峰面积响应值呈良好线性关系,平均回收率100.60%,RSD=1.96%;溶出度测定结果显示120min时溶出均大于75%。结论：该法制备工艺简单,易于操作,溶出度准确可靠。

Studies on Preparation of Baicalin Dispersible Tablets and Its Determination of Dissolution Rate

Objective：To study the preparation of baicalin dispersible tablet and determination of its dissolution rate.Methods：The excipients and baicalin were blended into a stable homogeneous mixture by using trituration.The tablets was prepared by using direct compression process and the dissolution of the tablets was determined by high performance liquid chromatography（HPLC） method.Results：The baicalin was provided with a good linear range of 10~100μ/mL;the average recovery was 100.60% and RSD of 1.96%;the cumulative dissolution percentage exceeded 75% in 120 min.Conclusion：The preparation method is simple and easy to operate.The dissolution result was stable and reliable.