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Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs
Affiliation:1. San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy;2. Laboratory of Tumor Inflammation and Angiogenesis, VIB-KULeuven, 3000 Leuven, Belgium;3. Cagliari University-Hospital, 09100 Cagliari, Italy;4. National Research Council, Institute for Biomedical Technologies, 20132 Milan, Italy;5. Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA;6. Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
Abstract:
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  • Keywords:mesenchymal stromal cells  hematopoietic support  hematopoietic stem and progenitor cells  genome editing  DNA-damage response
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