MicroRNA therapeutics: principles, expectations, and challenges |
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| Authors: | Rupaimoole Rajesha Han Hee-Dong Lopez-Berestein Gabriel Sood Anil K |
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| Affiliation: | Rajesha Rupaimoole1,4,Hee-Dong Han1,Gabriel Lopez-Berestein2,3,4 and Anil K.Sood1,4 Department of 1Gynecologic Oncology,2Experimental Therapeutics,and 3Department of Cancer Biology,4Center for RNA Interference and Non-Coding RNA,The University of Texas M.D.Anderson Cancer Center,Houston,Texas 77030,USA. |
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| Abstract: | MicroRNAs(miRNAs) are a class of highly abundant non-coding RNA molecules that are involved in several biological processes.Many miRNAs are often deregulated in several diseases including cancer.There is substantial interest in exploiting miRNAs for therapeutic applications.In this editorial,we briefly review current advances in the use of miRNAs or antisense oligonucleotides(antagomirs) for such therapies.One of the key issues related to therapy using miRNAs is degradation of naked particles in vivo.To ove... |
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| Keywords: | MicroRNA nanoparticles miRNA therapeutics DOPC chitosan |
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