| Study on the Effect of Ligustrazine on Hematopoietic Reconstitution in Bone Marrow Transplantation Mice |
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| 作者姓名： | 房明浩 孙汉英 刘文励 |
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| 作者单位： | Department of Internal Medicine，Tongji Hospital，Tongji Medical University，Wuhan 430030 |
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| 基金项目： | a grant from the National
Natural Science Fundation of China (No. 39870926). |
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| 摘 要： | Hematopoietic reconstitution after bone marrowtransplantation is a complicated process CXCchemokines and their receptors play important rolesin this process. One of these receptors, CXCR4 expresses on hematopoietic stem cells, and is now takenas a "homing factor" in hematopoietic reconstitu--'tionll' 2]. Ligustrazine can protect the bone marrowmicroenvironment after irradiation or immune damage', 4]. We established allogenic bone marrow transplantation mice models and explored the effects …
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| 收稿时间： | 12 March 2000 |
Study on the effect of ligustrazine on hematopoietic reconstitution in bone marrow transplantation mice |
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| Fang Minghao Postgraduate,Sun Hanying,Liu Wenli.Study on the Effect of Ligustrazine on Hematopoietic Reconstitution in Bone Marrow Transplantation Mice[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2000,20(2):120-122. |
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| Authors: | Fang Minghao Postgraduate Sun Hanying Liu Wenli |
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| Affiliation: | (1) Department of Internal Medicine, Tongji Hospital, Tongji Medical University, 430030 Wuhan |
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| Abstract: | To explore tile effects of ligustrazine on hematopoietic reconstitution and its mechanism after bone marrow transplantation (BMT), the allogenic BMT mice were given intra-abdominal injection of 2,mg ligustrazine twice a day. On the 1st, 7th, 14th, and 28th day after BMT, peripheral blood cells and bone marrow nuclear cells (BMNC) were counted, and the histological features were evaluated. On the 7th, 14th, 21st day after BMT, CXCR4 expression on the BMNC was assayed. The results showed that peripheral blood cell counts and BMNC counts in ligustrazine-treated group on the 7th, 14th, 28th day were higher than those in BMT group (P<0. 01 or P
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| Keywords: | bone marrow transplantation hematopoietic reconstitution CXC chemokine receptor 4 ligustrazine |
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