| 东亚钳蝎毒BmK-9-(2)对豚鼠心室肌细胞钠通道的影响 |
| |
| 引用本文： | 张文杰,张威,刘丽娟,钟国赣,葛敬岩.东亚钳蝎毒BmK-9-(2)对豚鼠心室肌细胞钠通道的影响[J].吉林大学学报(医学版),2000,26(6):568-570. |
| |
| 作者姓名： | 张文杰 张威 刘丽娟 钟国赣 葛敬岩 |
| |
| 作者单位： | 基础医学院生理教研室 吉林 长春130021 |
| |
| 摘 要： | 目的 :观察东亚钳蝎毒 Bm K- 9- (2 )对豚鼠心室肌细胞钠通道的作用。方法 :采用全细胞膜片钳方法。结果 :Bm K- 9- (2 )使钠通道峰值电流增加 2 7%。峰值钠电导增加 1 7%。钠通道未失活成分增加 8%。 Bm K- 9- (2 )对心肌细胞钙通道没有明显影响。结论 :Bm K- 9- (2 )可激活钠通道并使钠通道失活过程延长
|
| 关 键 词： | 东亚钳蝎毒三级提取物BmK-9-(2) Na~+通道 膜片钳 |
| 文章编号： | 0253-3707(2000)06－0568－03 |
| 修稿时间： | 1999年12月28日 |
Effect of BmK-9-(2) on cardiac sodium channels in Guinea-pig ventricular myocytes |
| |
| Zhang Wenjie,Zhang Wei,LIU Lijuan,Zhong Guogan,Ge Jingyan.Effect of BmK-9-(2) on cardiac sodium channels in Guinea-pig ventricular myocytes[J].Journal of Jilin University: Med Ed,2000,26(6):568-570. |
| |
| Authors: | Zhang Wenjie Zhang Wei LIU Lijuan Zhong Guogan Ge Jingyan |
| |
| Abstract: | ? Objective:To investigate the effect of the BmK9(2) on the sodium current in guineapig ventricular myocytes.Methods:The whole cell patchclamp technique was used.Results:The BmK9(2) increased the magnitude of the peak inward sodium current (27%),peak sodium conductace (17%) and the prolong time course of sodium channel inactivation (8%) and there was no effects on calcium channels.Conclusion:BmK9(2) can activate sodium channel and prolong the inactivated course of myocytes. |
| |
| Keywords: | BmK-9-(2) sodium channels patch-clap |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
