妊娠期肝功能损害孕妇生化指标与血小板4项参数的关系

目的　探讨妊娠期肝功能损害孕妇生化指标与血小板 4项参数的关系。方法　分析对比门诊随访正常孕妇 (2 8例 )、单纯ALT升高组患者 (3 0例 )及黄疸伴ALT升高组患者 (2 7例 )的血生化和血小板 4项参数。结果　单纯ALT升高组ALT、AST、DB、TBA、GGT均高于正常孕妇组 (P <0 .0 1)、TB、MPV均高于正常孕妇组 (P <0 .0 5 )、PCT、PLT低于正常孕妇组 (P <0 .0 5 ) ,而两组间ALP、PDW无显著性差异 (P >0 .0 5 ) ;黄疸伴ALT升高组ALT、AST、TB、DB、TBA、ALP均高于单纯ALT升高组 (P <0 .0 1)、MPV高于单纯ALT升高组 (P <0 .0 5 )、PCT、PLT低于单纯ALT升高组 (P <0 .0 5 ) ,而两组间GGT、PDW无显著性差异 (P >0 .0 5 )。所有 5 7例肝损害孕妇生化指标和PLT4项参数进行相关分析 ,其中MPV与ALT、AST、GGT均存在正相关 (P <0 .0 5 ) ;PLT与TB、DB存在负相关 (P <0 .0 1) ;PCT与TB、DB存在负相关 (P <0 .0 5 ) ;其余生化指标和PLT4项参数不存在相关性 (P >0 .0 5 )。结论　GGT、ALP可能不是判断妊娠期肝功能损害的敏感指标 ;黄疸引起妊娠肝损害孕妇PLT计数减少

The relation between serum biochemistry index and 4 parameters of PLT in pregnancies with livers injury

Objective To study the relationship between serum biochemistry index and 4 parameters of platelet in pregnancies with livers injury.Methods The serum biochemistry index and 4 parameters of PLT from 28 healthy pregnant women (Group A), 30 pregnancies with simple up\|going ALT (Group B) and 27 pregnant patients with jaundice and up\|going ALT(Group C) were analysed and compared.Results ALT, AST, DB, TBA and GGT of group B was higher than that of group A (P<0.01). Both TB and Mpv were higher than that in group A (P<0.05). But PCT and PLT were lower than that in group A(P<0.05). ALT, AST, TB, DB, TBA and ALP of group C was higher than that of group B (P<0.01). MPV of group C was higher than that of group B (P<0.05), but PCT and PLT of group C was lower than that of group B (P<0.05). All the biochemistry index of pregnancies with livers injury and 4 parameters of PLT had been analysed correlately. The positive correlations between MPV and ALT, MPV and AST(or GGT)(P<0.05), were found after relative analysis. On contrary, there were the negative correlations between PLT and TB, PLT and DB(P,p.01), PCT and TB, PCT and DB(P<0.05).Conclusions Maybe GGT and AlT were not sensitive indices to diagnose jaundice liver injury of the pregnant patients. The amount of PLT of the pregnant patients with livers injury caused by jaundice had been decreased.