| 可吸收性医用珊瑚人工骨的致突变性研究 |
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| 引用本文： | 关景芳 程琳 贾文英 聂卫 褚婕 姜华 史弘道. 可吸收性医用珊瑚人工骨的致突变性研究[J]. 吉林医学, 2004, 25(4): 43-44 |
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| 作者姓名： | 关景芳 程琳 贾文英 聂卫 褚婕 姜华 史弘道 |
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| 作者单位： | 天津市医药科学研究所 天津300070(关景芳，程琳，贾文英，聂卫，褚婕，姜华)，天津市医药科学研究所 天津300070(史弘道) |
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| 摘 要： | 目的评价珊瑚人工骨的遗传毒性。方法采用Ames试验;细胞染色体畸变试验和小鼠骨髓细胞微核试验。结果不同浓度的浸提液加与不加S9mix条件下Ames试验;细胞染色体畸变试验以及微核试验与阴性对照组比较无显著差异,结果为阴性。结论在本试验系统条件下,可吸收性珊瑚人工骨无致突变作用。
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| 关 键 词： | 珊瑚人工骨 Ames试验 染色体畸变 小鼠骨髓细胞微核试验 |
Experiment study on mutagenicity of coral artificial bone |
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| GUAN Jing-fang,CHENG Lin,JIA Wen-ying,et al.. Experiment study on mutagenicity of coral artificial bone[J]. Jilin Medical Journal, 2004, 25(4): 43-44 |
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| Authors: | GUAN Jing-fang CHENG Lin JIA Wen-ying et al. |
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| Abstract: | Objective The evaluation of genetic toxicity to coral artificial bone.Method Adopt Ames test,cell culture chro-mosomal technique and minute nucleus test.Result s The results showed that coral artificial bone with different doses/plate didn 't increase the number of reversion mutation in any of the4strains with or without S 9 mix in Ames test.In CHL cell chromosome aberration test,the result was with or not S 9 mix chromosome .the frequencies of micronucleus in PCE were not increased.Each group test results comparing with normal control group were no difference(P<0.05)Conclusion Coral artificial bone have not ge-netic toxicity. |
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| Keywords: | Coral artificial bone Ames Chromosomal abnormality Minute nucleus |
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