燕滨扶正胶囊治疗代偿期及失代偿期肝硬化临床疗效观察研究

目的 研究中药燕滨扶正胶囊治疗肝硬化（代偿期或失代偿期）临床疗效。方法 选择代偿期及失代偿期肝硬化患者41例,随机分为治疗组（21例）及对照组（20例）。治疗组给予燕滨扶正胶囊1500 mg/次,口服,2次/日。对照组给予扶正化瘀胶囊2500 mg/次,3次/日。两组疗程均为48周。两组依据病情给予抗病毒,护肝降酶、对症支持等一般治疗（替比夫定、甘利欣、消炎利胆片、茵栀黄胶囊等）,观察两组患者症状、血常规、肝功能、门静脉宽度、腹水、肝脏及脾脏形态。结果 中药燕滨扶正胶囊联合抗病毒药物可使代偿期及失代偿期肝硬化患者门静脉宽度、脾肿大回缩或复常,可使纤维化指标复常或大幅下降且肝脏功能好转或复常。结论 燕滨扶正胶囊可改善肝硬化。

Clinical observation on treatment of compensated stage and decompensated stage liver cirrhosis with Yanbinfuzheng capsule

Objective To observe the clinical effect on Yanbinruzheng capsule in the treatment of compensated stage and decompensated stage liver cirrhosis. Methods Total of 41 patients with compensated stage and decompensated stage liver cirrhosis were randomly assigned to treatment group （21 cases） and control group （20 cases）. Treatment group alone had Yanbinruzheng capsule 1500 mg once time, 2 times daily; control group received Yanbinruzheng capsule 2500 mg once time, 3 times a day. Two groups were treated for 48 weeks. According to the condition of individual patients, antiviral drugs, treatments that protect liver and lower transaminase and other supportive treatments may apply to both groups （telbivudine, diammonium glycyrrhizinate, Xiaoyanlidan tablets, Yinzhihuang capsule）. Results Observation indicated that the use of ＂Yanbinruzheng capsule＂ combined with antiviral drugs can improve the liver morphology, reduce the width of portal vein, shrink or normalize splenomegaly, significantly reduce or normalize the level of liver fibrosis. In contrast to the control group, treatment group has significantly improved liver function or normalized the liver function of patients with liver cirrhosis. Conclusions Yanbinruzheng capsule improves liver function and treats liver cirrhosis.