| 疱疹止痛灵治疗带状疱疹后遗神经痛的临床与实验研究 |
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| 引用本文： | 李有田,富琦,孙木,王绍.疱疹止痛灵治疗带状疱疹后遗神经痛的临床与实验研究[J].吉林大学学报(医学版),1999,25(6):721-724. |
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| 作者姓名： | 李有田 富琦 孙木 王绍 |
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| 作者单位： | 1. 吉林大学医学院第一临床学院中医科,长春,130021
2. 吉林大学医学院基础医学院生理教研室 |
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| 基金项目： | 吉林省中医药管理局科研项目;96A19; |
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| 摘 要： | 目的：为探讨疱疹止痛灵治疗带状疱疹后遗神经痛的效果和镇痛作用机理。方法：对疱疹止痛灵进行了系统的临床观察和动物实验研究。结果：临床应用疱疹止痛灵治疗带状疱疹后遗神经痛３１５ 例，总有效率９６．５％ ，而对照组７９ 例，总有效率 ４４．３％ ，结果显示治疗组优于对照组（Ｐ＜ ０．０１）。结论：经临床及实验研究结果表明，疱疹止痛灵不仅能有效治疗带状疱疹后遗神经痛，而且实验证明，疱疹止痛灵镇痛作用对于外周交感神经末稍有阻断作用 止痛作用，而对侧脑室给予疱疹止痛灵无镇痛作用。从而证明该药止痛部位在外周交感神经末稍，而不是神经中枢
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| 关 键 词： | 水痘-带状疱疹病毒 带状疱疹 后遗神经痛 疱疹止痛灵 中药镇痛 |
| 修稿时间： | 1999-06-11 |
Clinical and experimental studies on effect of herpetic neuralgia killer on postherpetic neuralgia |
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| Li Youtian,Fu Qi,Sun Mu,Wang Shao.Clinical and experimental studies on effect of herpetic neuralgia killer on postherpetic neuralgia[J].Journal of Jilin University: Med Ed,1999,25(6):721-724. |
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| Authors: | Li Youtian Fu Qi Sun Mu Wang Shao |
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| Affiliation: | 1\ The First Clinical College;2\ The School of Basic Medical Sciences |
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| Abstract: | Objective:To explore the effect of herpetic neuralgia killer (HNK) on treatment of postherpetic neuralgia and its analgesic mechanism.Methods:Clinical observation and animal experimental study were on effect of herpetic neuralgia killer.Results:315 cases were treated with HNK and 79 cases in control group,and the total effective rate was 96.5% and 44.3% respectively.Conclusion:The treated group had a better curative effect than the control group.The effect of HNK on treatment of postherpetic neuralgia was affirmative,which demonstrated that HNK could block the afferent transduction of sympathetic terminals.The HNK injected cerebroventricularly ahd no effect on analgesia.The location of analgesia is in the afferent transduction of sympathetic terminals,not in nerve centre. |
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| Keywords: | varicella zoster virus herpes zoster postherpetic neuralgia herpetic neuralgia killer analgesic study of the traditional Chinese medicine |
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