Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells |
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| Authors: | Qaisra Naheed Choudhry Mi Jeong Kim Tae Gyun Kim Jeong Hoon Pan Jun Ho Kim Sung Jin Park Jin Hyup Lee Young Jun Kim |
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| Affiliation: | Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea; (Q.N.C.); (M.J.K.); (T.G.K.); (J.H.P.); (J.H.K.); (S.J.P.); (J.H.L.) |
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| Abstract: | Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E. |
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| Keywords: | vitamin A vitamin E nanoemulsification saponin antioxidant capacity |
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