| 10种中草药抗炎有效成分对白三烯B_4生物合成的影响 |
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| 引用本文： | 欧阳瑜,付渝滨,尚京川,马育,邓文龙,周重楚.10种中草药抗炎有效成分对白三烯B_4生物合成的影响[J].中药药理与临床,1991(1). |
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| 作者姓名： | 欧阳瑜 付渝滨 尚京川 马育 邓文龙 周重楚 |
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| 作者单位： | 重庆医科大学，重庆医科大学，重庆医科大学，重庆医科大学，四川省中药研究所，吉林省中医中药研究院 重庆 630041，重庆 630041，重庆 630041，重庆 630041，重庆 630065 |
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| 摘 要： | 10种中药有效成分在体外对钙离子载体A_(23187)刺激人多形核白细胞产生白三烯B_4影响试验的结果表明:1×10~(-5)mol/L的大黄素的抑制率为100％,3×10~(-5)mol/L齐墩果酸的抑制率为45.5±4.4％,1×10~(-4)mol/L的放线瑞香宁、去氧胆酸等也有一定抑制作用。
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| 关 键 词： | 白三烯B_4 大黄素 齐墩果酸 放线瑞香宁 去氧胆酸 |
The Effect of Ten Antiinflammatory Components of Chinese Materia Medica on Biosynthesis of Leukotriene B4 |
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| Ouyang Yu,Fu Yubin,Shang Jingchuan,Ma Yu.The Effect of Ten Antiinflammatory Components of Chinese Materia Medica on Biosynthesis of Leukotriene B4[J].Pharmacology and Clinics of Chinese Materia Medica,1991(1). |
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| Authors: | Ouyang Yu Fu Yubin Shang Jingchuan Ma Yu |
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| Abstract: | In this study, the primary results of the effects of ten activity components of Chinese materia medica on Leukotriene B4 (LTB4) generation in human polymorphonuclear leukocytes stimulated by calcium Ionophore A23187 are reported.The biosynthesis of LTB4 was strongly inhibited by Emodin. Oleanolic acid, antinodaphnine and Deoxycholic acid showed certain suppression. Others did not give apparent inhibition activity. |
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| Keywords: | Leukotriene B_4 Emodin Oleanolic acid Antinodaphnine Deoxycholic acid Andrographolide Japonicumosides Ammonium glycyrrhetate Aloperine Aconitine Berberine |
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