脑星形细胞瘤磁敏感效应级别与1H-MR波谱相对定量的相关性探讨

目的探讨脑星形细胞瘤高分辨率磁敏感加权像(SWI)的瘤内磁敏感效应(ITSS)级别与多体素氢质子MR波谱(1H-MRS)相对定量的相关性,以评估对脑星形细胞瘤分级诊断的价值。方法搜集经病理证实的33例脑星形细胞瘤相关资料,根据33例SWI表现确定ITSS不同级别。多体素1H-MRS分别计算肿瘤实质区的胆碱(Cho)/肌酸(Cr),Cho/乙酰天冬氨酸(NAA)相对定量,并与ITSS分级进行相关性分析。结果高级别星形细胞瘤ITSS级别高于低级别星形细胞瘤(P0.01)。高级别星形细胞瘤Cho/Cr、Cho/NAA相对定量比值均高于低级别星形细胞瘤(P0.01)。ITSS级别越高Cho/Cr、Cho/NAA相对定量比值也越大,呈正相关性(r=0.763,r=0.741,P0.01)。结论脑星形细胞瘤ITSS级别与1H-MRS相对定量有较强的正相关性,ITSS级别可作为脑星形细胞瘤的分级诊断指标。

Correlation investigate between grade of intratumoral susceptibility signals and relative quantitative of 1H-MRS in patients with brain astrocytic tumours

Objective:To investigate the correlation between the grade of intratumoral susceptibility signals(ITSS) in high-resolution susceptibility-weighted imaging(SWI) and relative quantitative of multi-voxel 1H-MRS,and estimate its value on the grade of brain astrocytic tumours.Materials and Methods:The data of 33 patients with brain astrocytic tumours confirmed by postoperative pathologic were collected.Multi-voxel 1H-MRS calculates respectively the relative quantitative of Choline(Cho)/Creotine(Cr),Cho/N-acetylaspartate(NAA),and analyze with grade of ITSS correlation.Results:The high grade astrocytic tumours of ITSS classification was obviously higher than the low grade gliomas(P<0.01).The high grade astrocytic tumours of Cho/Cr,Cho/NAA relative quantitative ratio was obviously higher than the low grade astrocytic tumours(P<0.01).The higher the grade of ITSS was,the bigger the Cho/Cr,Cho/NAA of relative quantitative ratio was,which showed positive correlation(r=0.763,r=0.741,P<0.01).Conclusion:There is better positive correlation between grade of ITSS and relative quantitative of 1H-MRS in patients with brain astrocytic tumours.The grade of ITSS in brain astrocytic tumours can be used as classification diagnostic index.