| KAI1/CD82与C-erbB-2在乳腺癌中的表达及其临床意义 |
| |
| 引用本文： | 赵云霞,赵瑾,刘德纯,承泽农.KAI1/CD82与C-erbB-2在乳腺癌中的表达及其临床意义[J].蚌埠医学院学报,2011,36(10):1058-1060,1063. |
| |
| 作者姓名： | 赵云霞 赵瑾 刘德纯 承泽农 |
| |
| 作者单位： | 1. 蚌埠医学院病理生理学教研室, 安徽蚌埠 233030;2. 蚌埠医学院病理学教研室, 安徽蚌埠 233030 |
| |
| 基金项目： | 安徽省教育厅自然科学研究资助项目(KJ2010B122); 蚌埠医学院科研资助项目(BY0737) |
| |
| 摘 要： | 目的: 探讨KAI1/CD82及C-erbB-2在乳腺癌中的表达及其临床意义。方法: 采用免疫组织化学S-P法检测57例乳腺癌组织和11例乳腺良性病变组织中KAI1/CD82及C-erbB-2的表达,分析其与临床病理参数的关系。结果: 57例乳腺癌组织和11例乳腺良性病变组织中KAI1/CD82、C-erbB-2阳性率分别为31.58%和81.82%、71.93%和0.00%,差异均有统计学意义(P < 0.01)。乳腺癌患者中,淋巴结未转移、雌激素受体(ER)阴性者的KAI1/CD82阳性率高于淋巴结转移、ER阳性者(P <0.05);ER阳性患者C-erbB-2的阳性率低于ER阴性者(P < 0.05)。KAI1/CD82与C-erbB-2在乳腺癌中的表达无相关关系(P >0.05)。结论: KAI1/CD82和C-erbB-2均参与了乳腺癌的发生、发展过程,对乳腺癌的浸润和转移及预后评估具有临床参考意义。
|
| 关 键 词： | 乳腺肿瘤 KAI1/CD82 C-erbB-2 免疫组织化学 |
| 收稿时间： | 2010-11-26 |
Expression of KAI1/CD82 and C-erbB-2 in breast cancer and its clinical significance |
| |
| ZHAO Yun-xia,ZHAO Jin,LIU De-chun,CHENG Ze-nong.Expression of KAI1/CD82 and C-erbB-2 in breast cancer and its clinical significance[J].Journal of Bengbu Medical College,2011,36(10):1058-1060,1063. |
| |
| Authors: | ZHAO Yun-xia ZHAO Jin LIU De-chun CHENG Ze-nong |
| |
| Affiliation: | 1. Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui 233030, China;2. Department of Pathology, Bengbu Medical College, Bengbu Anhui 233030, China |
| |
| Abstract: | Objective:To explore the expression of KAI1/CD82 and C-erbB-2 in breast cancer and its clinieal significance.Methods:The expression of KAI1/CD82,C-erbB-2 and estrogen receptor(ER) in 57 cases of breast cancer and 11 cases of benign mammary lesions were detected by immunohistochemistry S-P method,and their correlation with the clinicopathologic features was analyzed.Results:The positive rate of KAI1/CD82 was 31.58% in the breast cancer and 81.82% in the benign mammary lesions.The positive rate of C-erbB-2 wa... |
| |
| Keywords: | breast neoplasms KAI1/CD82 C-erbB-2 immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《蚌埠医学院学报》浏览原始摘要信息 |
|
点击此处可从《蚌埠医学院学报》下载全文 |
