Mimengosides J and K: two new neuroprotective triterpenoids from the fruits of Buddleja lindleyana |
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| Authors: | Wei Zhang Zheng Li Feng-Qing Xu Ya-Shuo Ren Shuang-Wang Xu Tong-Sheng Wang |
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| Affiliation: | 1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;2. Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China;3. Key Laboratory of Xin’an medicine, Ministry of Education, Hefei 230012, China;4. Department of Pharmacy, Anhui Provincial Hospital, Hefei 230012, China |
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| Abstract: | Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1) and K (2), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP+) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease. 
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| Keywords: | Buddleja lindleyana mimengosides J and K triterpenoids MPP+induced neurotoxicity |
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