多体素H-MRS在脑胶质瘤术前评价中的应用 |
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引用本文: | 肖朝勇,刘文,许云,袁哲星,刘宏毅.多体素H-MRS在脑胶质瘤术前评价中的应用[J].临床神经外科杂志,2009,6(4):175-177,180. |
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作者姓名: | 肖朝勇 刘文 许云 袁哲星 刘宏毅 |
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作者单位: | 1. 210029,南京医科大学附属脑科医院放射科 2. 210029,南京医科大学附属脑科医院神经外科 |
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基金项目: | 南京市科技计划项目:200702076 |
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摘 要: | 目的运用多体素二维磁共振波谱法(H-MRS)分析脑胶质瘤周围区域。H-MRS代谢物改变特点,评价H-MRS在脑胶质瘤术前的应用价值。方法收集经手术及病理证实的28例胶质瘤患者,所有患者在术前均行磁共振头颅常规检查和。H-MRS检查。分别测量不同区域的N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)峰下面积,计算出NAA/Cr、Cho/Cr及NAA/Cho比值,并进行统计学分析。结果低/高级别胶质瘤肿瘤组织和对侧正常脑组织的NAA/Cr、Cho/Cr及NAA/Cho比值存在显著性差异;低/高级别胶质瘤肿瘤组织和远瘤周区域的NAA/Cr、Cho/Cr及NAA/Cho比值存在显著性差异;低级别胶质瘤远瘤周区域和对侧正常脑组织的NAA/Cho比值存在显著性差异,NAA/Cr、Cho/Cr比值不存在显著性差异;高级别胶质瘤远瘤周区域和对侧正常脑组织的Cho/Cr、NAA/Cho比值存在显著性差异,但NAA/Cr比值不存在显著性差异。结论多体素H-MRS可帮助临床医生在术前评价胶质瘤的浸润范围,并制定最佳的治疗方案。
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关 键 词: | 脑胶质瘤 磁共振波谱 多体素 氢质子 |
Clinical application of multivoxel 1H-MRS in preoperative evaluation of cerebral gliomas |
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Affiliation: | XIAO Chao-yong, LIU Wen, XU Yun, et al.( Department of Radiology, Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China) |
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Abstract: | Objective To analyze the metabolic characteristics and the changes by 2D muhivoxel proton magnetic resonance spectroscopy (H-MRS) and to evaluate application valne of H-MRS in the preoperation of gliomas. Methods 28 patients confirmed by pathology were performed by Routine MR and H-MRS. NAA, Cr and Cho peak area were detected in different areas, NAA/Cr, Cho/Cr and NAA/Cho ratio were calculated and analyzed statistically. Results Significant differences between low/high grade gliomas and normal brain tissues were found in the ratios of NAA/Cr, Cho/Cr and NAA/Cho. Significant differences between low/high grade gliomas and the far side peritumoral brain tissues were found in the ratios of NAA/Cr, Cho/Cr and NAA/ Cho. Significant differences between the far side peritumoral brain tissues of low grade gliomas and normal brain tissues were found in the ratios of NAA/Cho, but there were no significant differences in the ratios of NAA/Cr and Cho/Cr. Significant differences between the far side peritumoral brain tissues of high grade gliomas and normal brain tissues were found in the ratios of NAA/Cho and Cho/Cr, but there were no significant differences in the ratios of NAA/Cr. Conclusion H-MRS may be helpful to defining the border of brain glioma and designing the best the therapeutic protocols. |
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Keywords: | glioma magnetic resonancespectroscopy multivoxel proton |
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